Phenotypes associated with this allele

• Allele Symbol: Lepr^db-lb
• Allele Name: pound
• Allele ID: MGI:3714780
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lepr^db-lb/Lepr^db-lb	C57BL/6NCrl-Lepr^db-lb/Crl	MGI:5000099

Genotype
MGI:5000099

hm1

• Allelic Composition: Lepr^db-lb/Lepr^db-lb
• Genetic Background: C57BL/6NCrl-Lepr^db-lb/Crl

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased blood uric acid level ( J:171755 )

insulin resistance ( J:171755 )

• however, lowering uric acid improves insulin sensitivity

abnormal lipid level ( J:171755 )

• dyslipidemia

immune system

white adipose tissue inflammation ( J:171755 )

• mice exhibit increased macrophages infiltration within the visceral adipose tissue compared with wild-type mice

• however, lowering uric acid reduces inflammation

growth/size/body

obese ( J:171755 )

cardiovascular system

increased mean systemic arterial blood pressure ( J:171755 )

• however, lowering uric acid improves mean arterial blood pressure

adipose tissue

white adipose tissue inflammation ( J:171755 )

• mice exhibit increased macrophages infiltration within the visceral adipose tissue compared with wild-type mice

• however, lowering uric acid reduces inflammation

liver/biliary system

hepatic steatosis ( J:171755 )