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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pdgfrbtm1Mdt
targeted mutation 1, Michelle D Tallquist
MGI:3715030
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Pdgfrbtm1Mdt/Pdgfrbtm1Mdt
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: C57BL/6 * CBA MGI:3715095
cn2
 		Pdgfratm8Sor/Pdgfratm8Sor
Pdgfrbtm1Mdt/Pdgfrbtm1Mdt
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: C57BL/6 * CBA MGI:3715096


Genotype
MGI:3715095
cn1
Allelic
Composition		 Pdgfrbtm1Mdt/Pdgfrbtm1Mdt
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Pdgfrbtm1Mdt mutation (0 available); any Pdgfrb mutation (87 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
perimembraneous ventricular septal defect ( J:122584 )
• 8 of 10 mice exhibit perimenbraneous ventricular septal defects




Genotype
MGI:3715096
cn2
Allelic
Composition		 Pdgfratm8Sor/Pdgfratm8Sor
Pdgfrbtm1Mdt/Pdgfrbtm1Mdt
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (26 available)
Pdgfratm8Sor mutation (1 available); any Pdgfra mutation (88 available)
Pdgfrbtm1Mdt mutation (0 available); any Pdgfrb mutation (87 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, complete penetrance ( J:122584 )
• 100% of mice die after birth

cardiovascular system
persistent truncus arteriosus ( J:122584 )
• in 100% of mice
ventricular septal defect ( J:122584 )
• in 100% of mice

hematopoietic system
abnormal thymus development ( J:122584 )
• thymus development is aberrant
thymus hypoplasia ( J:122584 )
• thymus development is aberrant

craniofacial
cleft palate ( J:122584 )
• at birth

homeostasis/metabolism
cyanosis ( J:122584 )
• at birth

immune system
abnormal thymus development ( J:122584 )
• thymus development is aberrant
thymus hypoplasia ( J:122584 )
• thymus development is aberrant

digestive/alimentary system
cleft palate ( J:122584 )
• at birth

embryo
abnormal cardiac neural crest cell migration ( J:122584 )
• neural crest cell (NCC) migration defects occur in the conotruncus region
• NCCs fail to migrate to the thymic epithelium

cellular
abnormal cardiac neural crest cell migration ( J:122584 )
• NCCs fail to migrate to the thymic epithelium
• neural crest cell (NCC) migration defects occur in the conotruncus region

endocrine/exocrine glands
abnormal thymus development ( J:122584 )
• thymus development is aberrant
thymus hypoplasia ( J:122584 )
• thymus development is aberrant

growth/size/body
cleft palate ( J:122584 )
• at birth




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory