Analysis Tools
mortality/aging
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• by E16.5 to E17.5 no pups are recovered
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• non-Mendelian ratios are first found at E12.5 and by E16.5 to E17.5 no pups are recovered
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cellular
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• mouse embryonic cells exhibit reduced length of G1 phase and increased G2/M phase
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• without prior conditioning, mouse embryonic cells exhibit decreased viability when heat-shocked for 15 or 45 minutes
• increased viability following heat-shock was reduced when mouse embryonic cells were preconditioned
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• mouse embryonic cells exhibit reduced proliferation
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• mouse embryonic cells exhibit premature senescence
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liver/biliary system
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• at E13.5, the fetal liver mass is reduced in size with reduced hepatic parenchyma and enlarged venous sinusoids
• at E13.5, hepatocyte precursors are present in reduced numbers
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embryo
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• at E13.5, mice are smaller in size
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• at E13.5, hematopoietic precursors are present in reduced numbers
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growth/size/body
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• at E13.5, mice are smaller in size
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hematopoietic system
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• at E13.5, hematopoietic precursors are present in reduced numbers
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