Phenotypes associated with this allele

• Allele Symbol: Epb41l5^{Gt(AE0088)Wtsi}
• Allele Name: gene trap AE0088, Wellcome Trust Sanger Institute
• Allele ID: MGI:3715119
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Epb41l5^Gt(AE0088)Wtsi/Epb41l5^Gt(AE0088)Wtsi	involves: C57BL/6J	MGI:3715171
ht2	Epb41l5^Gt(AE0088)Wtsi/Epb41l5^lulu	involves: C57BL/6J	MGI:3715174

Genotype
MGI:3715171

hm1

• Allelic Composition: Epb41l5^{Gt(AE0088)Wtsi}/Epb41l5^{Gt(AE0088)Wtsi}
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between somite formation and embryo turning ( J:122548 )

• phenotype is stated to be identical to that of Epb4.1l5^lulu homozygotes; however no data is presented

embryo

abnormal rostral-caudal body axis extension ( J:122548 )

embryonic growth arrest ( J:122548 )

abnormal embryonic tissue morphology ( J:122548 )

abnormal primitive streak morphology ( J:122548 )

abnormal extraembryonic tissue morphology ( J:122548 )

Genotype
MGI:3715174

ht2

• Allelic Composition: Epb41l5^{Gt(AE0088)Wtsi}/Epb41l5^lulu
• Genetic Background: involves: C57BL/6J

mortality/aging

embryonic lethality between somite formation and embryo turning ( J:122548 )

• embryos recapitulate Epb4.1l5^lulu phenotype

embryo

abnormal rostral-caudal body axis extension ( J:122548 )

• at E8.5, embryos have shortened trunks

abnormal neural plate morphology ( J:122548 )

• at E8.5, anterior neural plate is broad, open, and folded into irregular ridges, and thicker than in wild-type

absent somites ( J:122548 )

• embryos lack visible somites at E8.5

nervous system

abnormal neural plate morphology ( J:122548 )

• at E8.5, anterior neural plate is broad, open, and folded into irregular ridges, and thicker than in wild-type