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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Hprt1tm1(UBC-UBB)Rrk
targeted mutation 1, Ron R Kopito
MGI:3715138
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Hprt1tm1(UBC-UBB)Rrk/Hprt1tm1(UBC-UBB)Rrk
Ubctm1Rrk/Ubctm1Rrk 		involves: 129 * C57BL/6J MGI:3715159
cx2
 		Hprt1tm1(UBC-UBB)Rrk/Y
Ubctm1Rrk/Ubctm1Rrk 		involves: 129 * C57BL/6J MGI:3715160


Genotype
MGI:3715159
cx1
Allelic
Composition		 Hprt1tm1(UBC-UBB)Rrk/Hprt1tm1(UBC-UBB)Rrk
Ubctm1Rrk/Ubctm1Rrk
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm1(UBC-UBB)Rrk mutation (0 available); any Hprt1 mutation (1280 available)
Ubctm1Rrk mutation (0 available); any Ubc mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, complete penetrance ( J:122574 )
• despite recovering pups at E17.5, no live pups are born

cellular
cellular phenotype ( J:122574 )
N
• mouse embryonic cells exhibit normal proliferation and senescence

liver/biliary system
liver/biliary system phenotype ( J:122574 )
N
• the liver develops normally

embryo
decreased embryo size ( J:122574 )
• at E17.5, mice are smaller overall

growth/size/body
decreased embryo size ( J:122574 )
• at E17.5, mice are smaller overall




Genotype
MGI:3715160
cx2
Allelic
Composition		 Hprt1tm1(UBC-UBB)Rrk/Y
Ubctm1Rrk/Ubctm1Rrk
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm1(UBC-UBB)Rrk mutation (0 available); any Hprt1 mutation (1280 available)
Ubctm1Rrk mutation (0 available); any Ubc mutation (5 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, complete penetrance ( J:122574 )
• despite recovering pups at E17.5, no live pups are born

cellular
cellular phenotype ( J:122574 )
N
• mouse embryonic cells exhibit normal proliferation and senescence

liver/biliary system
liver/biliary system phenotype ( J:122574 )
N
• the liver develops normally

embryo
decreased embryo size ( J:122574 )
• at E17.5, mice are smaller overall

growth/size/body
decreased embryo size ( J:122574 )
• at E17.5, mice are smaller overall




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory