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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sun1tm1Mhan
targeted mutation 1, Min Han
MGI:3715140
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sun1tm1Mhan/Sun1tm1Mhan B6.129S6-Sun1tm1Mhan MGI:5566679
hm2
 		Sun1tm1Mhan/Sun1tm1Mhan involves: 129S6/SvEvTac MGI:3715729
hm3
 		Sun1tm1Mhan/Sun1tm1Mhan involves: 129S6/SvEvTac * C57BL/6J MGI:5615704
cx4
 		Sun1tm1Mhan/Sun1+
Sun2tm1Mhan/Sun2tm1Mhan 		involves: 129S6/SvEvTac MGI:3850094
cx5
 		Sun1tm1Mhan/Sun1tm1Mhan
Sun2tm1Mhan/Sun2tm1Mhan 		involves: 129S6/SvEvTac MGI:3850092
cx6
 		Sun1tm1Mhan/Sun1tm1Mhan
Sun2tm1Mhan/Sun2+ 		involves: 129S6/SvEvTac MGI:3850093
cx7
 		Rad21ltm1Yow/Rad21ltm1Yow
Sun1tm1Mhan/Sun1tm1Mhan 		involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj MGI:5615731


Genotype
MGI:5566679
hm1
Allelic
Composition		 Sun1tm1Mhan/Sun1tm1Mhan
Genetic
Background		 B6.129S6-Sun1tm1Mhan
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sun1tm1Mhan mutation (1 available); any Sun1 mutation (64 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal male meiosis ( J:205574 )
• chromosome movement is impaired
• defect in telomere-nuclear envelope attachment
abnormal meiotic attachment of telomere to nuclear envelope ( J:205574 )
• defect in telomere-nuclear envelope attachment

cellular
abnormal male meiosis ( J:205574 )
• chromosome movement is impaired
• defect in telomere-nuclear envelope attachment
abnormal meiotic attachment of telomere to nuclear envelope ( J:205574 )
• defect in telomere-nuclear envelope attachment




Genotype
MGI:3715729
hm2
Allelic
Composition		 Sun1tm1Mhan/Sun1tm1Mhan
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sun1tm1Mhan mutation (1 available); any Sun1 mutation (64 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
absent oocytes ( J:122602 )
• no oocytes are detected at day 5
abnormal spermatocyte morphology ( J:122602 )
• only abnormal spermatocyte-like cells are present
decreased male germ cell number ( J:122602 )
• germ cells are largely depleted in seminiferous tubules
• spermatids and spermatozoa are completely absent
abnormal chromosomal synapsis ( J:122602 )
• no spermatocytes show normal homologous pairing and synapsis
abnormal female meiosis ( J:122602 )
• oocytes fail to form normal nuclear attachment and clustering of telomeres
• very rarely are pachytene-like structures observed
arrest of male meiosis ( J:122602 )
• spermatogenesis is arrested in meiotic prophase
• spermatocytes fail to form normal nuclear attachment and clustering of telomeres
• no spermatocytes show normal homologous pairing and synapsis
increased ovary apoptosis ( J:122602 )
• at E17.5, ovaries have increased apoptotic signal
increased testis apoptosis ( J:122602 )
• apoptotic signal in the seminiferous tubules is increased

cellular
absent oocytes ( J:122602 )
• no oocytes are detected at day 5
abnormal spermatocyte morphology ( J:122602 )
• only abnormal spermatocyte-like cells are present
decreased male germ cell number ( J:122602 )
• germ cells are largely depleted in seminiferous tubules
• spermatids and spermatozoa are completely absent
abnormal chromosomal synapsis ( J:122602 )
• no spermatocytes show normal homologous pairing and synapsis
abnormal female meiosis ( J:122602 )
• oocytes fail to form normal nuclear attachment and clustering of telomeres
• very rarely are pachytene-like structures observed
arrest of male meiosis ( J:122602 )
• spermatogenesis is arrested in meiotic prophase
• spermatocytes fail to form normal nuclear attachment and clustering of telomeres
• no spermatocytes show normal homologous pairing and synapsis
increased ovary apoptosis ( J:122602 )
• at E17.5, ovaries have increased apoptotic signal
increased testis apoptosis ( J:122602 )
• apoptotic signal in the seminiferous tubules is increased

hearing/vestibular/ear
abnormal cochlear outer hair cell morphology ( J:194486 )
• outer hair cells exhibit abnormal positioning of the nucleus compared with wild-type mice

behavior/neurological

muscle
abnormal muscle morphology ( J:150047 )
• mice exhibit a modest decrease in the average number of synaptic nuclei beneath the neuromuscular junctions compared with wild-type mice

nervous system
abnormal cochlear outer hair cell morphology ( J:194486 )
• outer hair cells exhibit abnormal positioning of the nucleus compared with wild-type mice

endocrine/exocrine glands
increased ovary apoptosis ( J:122602 )
• at E17.5, ovaries have increased apoptotic signal
increased testis apoptosis ( J:122602 )
• apoptotic signal in the seminiferous tubules is increased




Genotype
MGI:5615704
hm3
Allelic
Composition		 Sun1tm1Mhan/Sun1tm1Mhan
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sun1tm1Mhan mutation (1 available); any Sun1 mutation (64 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal chromosomal synapsis ( J:209347 )
• spermatocytes retain meiotic homolog pairing ability, although less than that of wild-type spermatocytes
• homolog association and pairing progress slowly in spermatocytes
abnormal male meiosis ( J:209347 )
• spermatocytes retain meiotic homolog pairing ability, although less than that of wild-type spermatocytes
• the initial chromosome association at the early leptotene stage is delayed in spermatocytes, indicating that homolog association and pairing progress slowly in spermatocytes

cellular
abnormal chromosomal synapsis ( J:209347 )
• spermatocytes retain meiotic homolog pairing ability, although less than that of wild-type spermatocytes
• homolog association and pairing progress slowly in spermatocytes
abnormal male meiosis ( J:209347 )
• spermatocytes retain meiotic homolog pairing ability, although less than that of wild-type spermatocytes
• the initial chromosome association at the early leptotene stage is delayed in spermatocytes, indicating that homolog association and pairing progress slowly in spermatocytes




Genotype
MGI:3850094
cx4
Allelic
Composition		 Sun1tm1Mhan/Sun1+
Sun2tm1Mhan/Sun2tm1Mhan
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sun1tm1Mhan mutation (1 available); any Sun1 mutation (64 available)
Sun2tm1Mhan mutation (1 available); any Sun2 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
abnormal muscle morphology ( J:150047 )
• 49% of muscle cells have no nuclei beneath neuromuscular junctions unlike in wild-type mice




Genotype
MGI:3850092
cx5
Allelic
Composition		 Sun1tm1Mhan/Sun1tm1Mhan
Sun2tm1Mhan/Sun2tm1Mhan
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sun1tm1Mhan mutation (1 available); any Sun1 mutation (64 available)
Sun2tm1Mhan mutation (1 available); any Sun2 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:150047 )
• mice die soon after birth
• however, neural expression of Unc84b rescues neonatal lethality

muscle
abnormal muscle morphology ( J:150047 )
• 81% of muscle cells have no nuclei beneath neuromuscular junctions unlike in wild-type mice

growth/size/body
decreased birth body size ( J:150047 )
• reduced body size at birth

homeostasis/metabolism
cyanosis ( J:150047 )
• at birth




Genotype
MGI:3850093
cx6
Allelic
Composition		 Sun1tm1Mhan/Sun1tm1Mhan
Sun2tm1Mhan/Sun2+
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sun1tm1Mhan mutation (1 available); any Sun1 mutation (64 available)
Sun2tm1Mhan mutation (1 available); any Sun2 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
muscle
abnormal muscle morphology ( J:150047 )
• 63% of muscle cells have no nuclei beneath neuromuscular junctions unlike in wild-type mice




Genotype
MGI:5615731
cx7
Allelic
Composition		 Rad21ltm1Yow/Rad21ltm1Yow
Sun1tm1Mhan/Sun1tm1Mhan
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad21ltm1Yow mutation (1 available); any Rad21l mutation (34 available)
Sun1tm1Mhan mutation (1 available); any Sun1 mutation (64 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system

cellular




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory