Phenotypes associated with this allele

• Allele Symbol: Mx1^r
• Allele Name: myxovirus resistance
• Allele ID: MGI:3715151
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mx1^r/Mx1^r	A2G	MGI:3718027
hm2	Mx1^r/Mx1^r	B6.A2G-Mx1^r	MGI:3715199
hm3	Mx1^r/Mx1^r	C.A2G-Mx1^r	MGI:3718023

Genotype
MGI:3718027

hm1

• Allelic Composition: Mx1^r/Mx1^r
• Genetic Background: A2G

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:23752 )

• following subcutaneous or intracerebral infection with Thogoto virus or intraperitoneal infection followed by treatment with the interferon-inducer poly(I)-poly(C), no mice die

immune system

decreased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:23752 )

• following subcutaneous or intracerebral infection with Thogoto virus or intraperitoneal infection followed by treatment with the interferon-inducer poly(I)-poly(C), no mice die

Genotype
MGI:3715199

hm2

• Allelic Composition: Mx1^r/Mx1^r
• Genetic Background: B6.A2G-Mx1^r

mortality/aging

decreased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:23752 )

• following intraperitoneal infection with Thogoto virus, no mice die

immune system

abnormal susceptibility to infection ( J:120938 )

• LD50 for hvPR8 is less than 10² plaque forming units

• LD50 for lvPR8 is greater than 10⁶ plaque forming units

• however, IFN treatment increases resistance to hvPR8

decreased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:23752 )

• following intraperitoneal infection with Thogoto virus, no mice die

Genotype
MGI:3718023

hm3

• Allelic Composition: Mx1^r/Mx1^r
• Genetic Background: C.A2G-Mx1^r

mortality/aging

decreased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:23752 )

• following intraperitoneal or subcutaneous infection with Thogoto virus, no mice die

immune system

decreased susceptibility to Orthomyxoviridae infection ( J:23752 )

• no Thogoto virus can be detected following infection compared to titers of 10^7.5 in 50% of tissues in control BALB/c mice

• treatment with INF inhibits Thogoto virus multiplication in embryo cells

decreased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:23752 )

• following intraperitoneal or subcutaneous infection with Thogoto virus, no mice die