All Phenotypes Mx1<r> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mx1^r
myxovirus resistance
MGI:3715151

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mx1^r/Mx1^r	A2G	MGI:3718027
hm2	Mx1^r/Mx1^r	B6.A2G-Mx1^r	MGI:3715199
hm3	Mx1^r/Mx1^r	C.A2G-Mx1^r	MGI:3718023

Allelic Composition	Mx1^r/Mx1^r
Genetic Background	A2G

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mx1^r mutation (1 available); any Mx1 mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:23752 )

• following subcutaneous or intracerebral infection with Thogoto virus or intraperitoneal infection followed by treatment with the interferon-inducer poly(I)-poly(C), no mice die

immune system

decreased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:23752 )

• following subcutaneous or intracerebral infection with Thogoto virus or intraperitoneal infection followed by treatment with the interferon-inducer poly(I)-poly(C), no mice die

Allelic Composition	Mx1^r/Mx1^r
Genetic Background	B6.A2G-Mx1^r

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mx1^r mutation (1 available); any Mx1 mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:23752 )

• following intraperitoneal infection with Thogoto virus, no mice die

immune system

abnormal susceptibility to infection ( J:120938 )

• LD50 for hvPR8 is less than 10² plaque forming units

• LD50 for lvPR8 is greater than 10⁶ plaque forming units

• however, IFN treatment increases resistance to hvPR8

decreased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:23752 )

• following intraperitoneal infection with Thogoto virus, no mice die

Allelic Composition	Mx1^r/Mx1^r
Genetic Background	C.A2G-Mx1^r

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mx1^r mutation (1 available); any Mx1 mutation (80 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:23752 )

• following intraperitoneal or subcutaneous infection with Thogoto virus, no mice die

immune system

decreased susceptibility to Orthomyxoviridae infection ( J:23752 )

• no Thogoto virus can be detected following infection compared to titers of 10^7.5 in 50% of tissues in control BALB/c mice

• treatment with INF inhibits Thogoto virus multiplication in embryo cells

decreased susceptibility to Orthomyxoviridae infection induced morbidity/mortality ( J:23752 )

• following intraperitoneal or subcutaneous infection with Thogoto virus, no mice die

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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