Phenotypes associated with this allele

• Allele Symbol: Hs6st1^tm1Kkm
• Allele Name: targeted mutation 1, Koji Kimata
• Allele ID: MGI:3715259
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hs6st1^tm1Kkm/Hs6st1^tm1Kkm	involves: 129P2/OlaHsd * BALB/c	MGI:3715266
hm2	Hs6st1^tm1Kkm/Hs6st1^tm1Kkm	involves: 129P2/OlaHsd * C3H/He	MGI:3715265
hm3	Hs6st1^tm1Kkm/Hs6st1^tm1Kkm	involves: 129P2/OlaHsd * C57BL/6	MGI:3715264
cx4	Hs6st1^tm1Kkm/Hs6st1^tm1Kkm Hs6st2^tm1.1Kkm/Hs6st2^tm1.1Kkm	involves: 129P2/OlaHsd	MGI:3798457

Genotype
MGI:3715266

hm1

• Allelic Composition: Hs6st1^tm1Kkm/Hs6st1^tm1Kkm
• Genetic Background: involves: 129P2/OlaHsd * BALB/c

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:122656 )

• Background Sensitivity: mice die between E15.5 and prenatal stages with no mice being born on a BALB/c background

Genotype
MGI:3715265

hm2

• Allelic Composition: Hs6st1^tm1Kkm/Hs6st1^tm1Kkm
• Genetic Background: involves: 129P2/OlaHsd * C3H/He

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:122656 )

• Background Sensitivity: mice die between E15.5 and prenatal stages with 7% of mice surviving into adulthood on a C3H/He background

Genotype
MGI:3715264

hm3

• Allelic Composition: Hs6st1^tm1Kkm/Hs6st1^tm1Kkm
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Hs6st1^tm1Kkm/Hs6st1^tm1Kkm mice exhibit growth retardation and abnormal eye, phalanges, and tarsus morphology

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:122656 )

• Background Sensitivity: mice die between E15.5 and prenatal stages with 4% of mice surviving into adulthood on a C57BL/6 background

embryo

abnormal placenta vasculature ( J:122656 )

• fewer red blood cells are found in the placenta

• placenta angiogenesis is disrupted

• 60% fewer microvessels are present compared to in wild-type mice

decreased embryo size ( J:122656 )

skeleton

abnormal phalanx morphology ( J:122656 )

• hind limb phalanges are missing

abnormal tarsal bone morphology ( J:122656 )

• hind limb tarsus is either smaller or missing

abnormal skeleton development ( J:122656 )

• morphogenesis is retarded in the limb skeleton

respiratory system

abnormal pulmonary alveolus morphology ( J:122656 )

• mice exhibit alveolar enlargement that is more pronounced in adult mice

vision/eye

abnormal eye morphology ( J:122656 )

• half of mice have abnormal eye morphology

growth/size/body

decreased embryo size ( J:122656 )

decreased body size ( J:122656 )

postnatal growth retardation ( J:122656 )

limbs/digits/tail

abnormal phalanx morphology ( J:122656 )

• hind limb phalanges are missing

abnormal tarsal bone morphology ( J:122656 )

• hind limb tarsus is either smaller or missing

cardiovascular system

abnormal placenta vasculature ( J:122656 )

• fewer red blood cells are found in the placenta

• placenta angiogenesis is disrupted

• 60% fewer microvessels are present compared to in wild-type mice

Genotype
MGI:3798457

cx4

• Allelic Composition: Hs6st1^tm1Kkm/Hs6st1^tm1Kkm; Hs6st2^tm1.1Kkm/Hs6st2^tm1.1Kkm
• Genetic Background: involves: 129P2/OlaHsd

cellular

decreased cell proliferation ( J:136555 )

♀ • decrease in FGF1-, FGF2-, and FGF3-induced cell proliferation in double homozygous MEFs