Phenotypes associated with this allele

• Allele Symbol: Mesp2^{tm13.1(cre/Esr1*)Ysa}
• Allele Name: targeted mutation 13.1, Yumiko Saga
• Allele ID: MGI:3715271
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mesp2^tm13.1(cre/Esr1*)Ysa/Mesp2^tm13.1(cre/Esr1*)Ysa	involves: C57BL/6 * SJL	MGI:3715274
hm2	Mesp2^tm13.1(cre/Esr1*)Ysa/Mesp2^tm13.1(cre/Esr1*)Ysa	Not Specified	MGI:3817259
ht3	Mesp2^tm13.1(cre/Esr1*)Ysa/Mesp2^tm17.1(VP16/Rbpj)Ysa	involves: C57BL/6 * CBA	MGI:4867480

Genotype
MGI:3715274

hm1

• Allelic Composition: Mesp2^{tm13.1(cre/Esr1*)Ysa}/Mesp2^{tm13.1(cre/Esr1*)Ysa}
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal somite development ( J:122532 )

• while somite development is abnormal, mice exhibit longer tails, more regular dermomyotmes and exhibit an external appearance of somite formation when compared to Mesp2^{tm13(cre/Esr1)Ysa} homozygotes

• at E10.5, mice do not exhibit epithelial somite formation

abnormal somite border morphology ( J:122532 )

• somite boundaries that form are incomplete and often contain clusters of cells which belong to neither of the neighboring somites

incomplete somite formation ( J:122532 )

• at E11.5, mice exhibit incomplete epithelial somites

Genotype
MGI:3817259

hm2

• Allelic Composition: Mesp2^{tm13.1(cre/Esr1*)Ysa}/Mesp2^{tm13.1(cre/Esr1*)Ysa}
• Genetic Background: Not Specified

skeleton

rib fusion ( J:141112 , J:167045 )

• the proximal regions fuse (J:167045)

abnormal vertebrae morphology ( J:141112 )

• mice exhibit incompletely segmented vertebrae unlike in wild-type mice

fusion of vertebral arches ( J:167045 )

• the pedicles of the neural arches fuse with their neighbors

short vertebral column ( J:141112 )

embryo

abnormal somite development ( J:167045 )

• partially segmented somites at E10.5

abnormal rostral-caudal patterning of the somites ( J:167045 )

• expression analysis indicates impaired rostral-caudal patterning

growth/size/body

decreased body length ( J:167045 )

• short trunk

limbs/digits/tail

short tail ( J:167045 )

• rudimentary tail

Genotype
MGI:4867480

ht3

• Allelic Composition: Mesp2^{tm13.1(cre/Esr1*)Ysa}/Mesp2^{tm17.1(VP16/Rbpj)Ysa}
• Genetic Background: involves: C57BL/6 * CBA

skeleton

fusion of vertebral arches ( J:167045 )

• the pedicles of the neural arches fuse with their neighbors

• the degree of fusion is increased compared to mice homozygous for Mesp2 ^{tm13.1(cre/Esr1*)Ysa}