Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(KRT14-Hr)551Cct transgene insertion 551, Catherine C Thompson MGI:3715279 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• by P22, mice exhibit hair loss; however mice regenerate hair and display thick fur by P28
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• at P22, follicle morphology is abnormal; by P28, regenerated hair follicles resemble wild-type follicles
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• abnormal epidermal structures (utricles) form by P22
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• sebaceous gland development is delayed in these mice with no glands present in the hair follicles at 9 days of age but are visible in some hair follicles by 12 days of age
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• sebaceous gland development is delayed in these mice with no glands present in the hair follicles at 9 days of age but are visible in some hair follicles by 12 days of age
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• hairs found in follicles at 9 days of age are shorter than those found in non-transgenic controls
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• the matrix cells associated with the hair follicle root sheath are proliferating at a slower rate compared to non-transgenic controls
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• the back skin of 9 day old mice is thicker than in non-transgenic controls due to an increase in undifferentiated skin cells and a decrease in terminally-differentiated keratinocytes
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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