Phenotypes associated with this allele

• Allele Symbol: Oc90^tm1Ywl
• Allele Name: targeted mutation 1, Yunxia Wang Lundberg
• Allele ID: MGI:3715290
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Oc90^tm1Ywl/Oc90^tm1Ywl	involves: 129P2/OlaHsd * C57BL/6J	MGI:3715293

Genotype
MGI:3715293

hm1

• Allelic Composition: Oc90^tm1Ywl/Oc90^tm1Ywl
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

abnormal tectorial membrane morphology ( J:122533 )

• cupula and tectorial membranes are thinner (15.7+/-2.6um compared to 32.5+/-2.5um in wild-type mice)

• the acellular matrix that give rise to the tectorial membrane is thinner

abnormal utricle morphology ( J:122533 )

• utricle and saccule otolith membranes appear brittle, less compact and frequently break

abnormal vestibular saccule morphology ( J:122533 )

• utricle and saccule otolith membranes appear brittle, less compact and frequently break

abnormal otolith morphology ( J:122533 )

• an organic matrix is lacking

• more than 75% of mice exhibit otoliths that do not securely adhere to the membranous honeycomb layer

• loose otoliths are occasionally displaced into the semi-circular canals or become associated with the roof

• utricle and saccule otolith membranes appear brittle, less compact and frequently break

• however, other inner ear structures including all epithelial cells are normal

decreased otolith number ( J:122533 )

enlarged otoliths ( J:122533 )

• enlarged otoliths are visible early in development at E16.5

• otoliths contain dark crystal deposits