Phenotypes associated with this allele

• Allele Symbol: Pcp2^{tm1(tTA)23Atai}
• Allele Name: targeted mutation 23, Atsu Aiba
• Allele ID: MGI:3715310
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Grm1^tm1Stl/Grm1^tm1Stl Pcp2^tm1(tTA)23Atai/Pcp2^+ Tg(tetO-Grm1)7Atai/?	involves: 129S2/SvPas * C57BL/6N	MGI:3715322

Genotype
MGI:3715322

cx1

• Allelic Composition: Grm1^tm1Stl/Grm1^tm1Stl; Pcp2^{tm1(tTA)23Atai}/Pcp2⁺; Tg(tetO-Grm1)7Atai/?
• Genetic Background: involves: 129S2/SvPas * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:122536 )

N • ataxic gait seen in Grm1^tm1Stl homozygotes is rescued by the active transgene

abnormal behavior ( J:122536 )

abnormal motor coordination/balance ( J:122536 )

• following treatment with doxycycline begun at P24, mice fall off a rotating rod immediately and after several trials the average retention time is less than in wild-type mice at 41 days post treatment

abnormal gait ( J:122536 )

• following treatment with doxycycline begun at P24, mice have abnormal gaits and steps with different degrees of severity at 37 days post treatment