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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Syt5tm2Sud
targeted mutation 2, Thomas C Sudhof
MGI:3715453
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Syt5tm2Sud/Syt5tm2Sud involves: 129S1/Sv * 129X1/SvJ MGI:3715457
cn2
 		Syt5tm2Sud/Syt5tm2Sud involves: 129S1/Sv * 129X1/SvJ MGI:3715455


Genotype
MGI:3715457
hm1
Allelic
Composition		 Syt5tm2Sud/Syt5tm2Sud
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syt5tm2Sud mutation (0 available); any Syt5 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:122459 )
N
• inhibitions of postsynaptic currents is normal




Genotype
MGI:3715455
cn2
Allelic
Composition		 Syt5tm2Sud/Syt5tm2Sud
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syt5tm2Sud mutation (0 available); any Syt5 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal inhibitory postsynaptic currents ( J:122459 )
• following infection with a lentivirus expression cre, inhibitions of postsynaptic currents (IPSCs) are severely impaired (63% decreased in synaptic amplitude)




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory