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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Glultm1Whla
targeted mutation 1, Wouter H Lamers
MGI:3715484
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Glultm1Whla/Glultm1Whla FVBHanHsd.129P2-Glultm1Whla MGI:3715615
ht2
Glultm1Whla/Glultm2Whla involves: 129P2/OlaHsd MGI:3715614
cn3
Glultm3Whla/Glultm1Whla
Tg(Ckmm-cre)5Khn/0
involves: 129P2/OlaHsd * FVB MGI:4462798
cn4
Glultm3Whla/Glultm1Whla
Tg(GFAP-cre)25Mes/0
involves: 129P2/OlaHsd * FVB/N MGI:4462796


Genotype
MGI:3715615
hm1
Allelic
Composition
Glultm1Whla/Glultm1Whla
Genetic
Background
FVBHanHsd.129P2-Glultm1Whla
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glultm1Whla mutation (0 available); any Glul mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice are at sub-Mendelian ratios at E3.5 and none are present at E9.5
• however, culturing embryos with L-glutamine increases survival in culture and proliferation is no different than cultured wild-type embryos
• mice are at sub-Mendelian ratios at E3.5 and none are present at E9.5




Genotype
MGI:3715614
ht2
Allelic
Composition
Glultm1Whla/Glultm2Whla
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glultm1Whla mutation (0 available); any Glul mutation (35 available)
Glultm2Whla mutation (0 available); any Glul mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:4462798
cn3
Allelic
Composition
Glultm3Whla/Glultm1Whla
Tg(Ckmm-cre)5Khn/0
Genetic
Background
involves: 129P2/OlaHsd * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glultm1Whla mutation (0 available); any Glul mutation (35 available)
Glultm3Whla mutation (1 available); any Glul mutation (35 available)
Tg(Ckmm-cre)5Khn mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• 35% increase in branched-chain amino acids
• muscle glutamine 20-30% lower
• 20% reduction in plasma glutamine in starved mice
• detoxification of ammonia is two fold lower

growth/size/body
• faster weight loss when fasting but only for the first 20 hours




Genotype
MGI:4462796
cn4
Allelic
Composition
Glultm3Whla/Glultm1Whla
Tg(GFAP-cre)25Mes/0
Genetic
Background
involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glultm1Whla mutation (0 available); any Glul mutation (35 available)
Glultm3Whla mutation (1 available); any Glul mutation (35 available)
Tg(GFAP-cre)25Mes mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• born in normal numbers
• none found at 6-8 days of age
• death at 2-3 days of age

behavior/neurological
• nursed immediately after birth but milk intake then declined

nervous system
• moderately elevated brain ammonia levels
• no gross brain malformations

homeostasis/metabolism
• decreased alanine in the cortex of the brain at two days of age
• decreased glutamine in the cortex of the brain at two days of age
• increased glycine in the cortex of the brain at two days of age
• moderately elevated brain ammonia levels
• blood glucose levels at 30% of controls at 2 days of age





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory