Analysis Tools
cellular
azoospermia
(
J:122381
)
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• males have absence of spermatozoa in most seminiferous tubules
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• retains vacuolated fetal zone X, which is absent in wild-type animals that progress through puberty
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growth/size/body
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• at 2 months of age, mice are significantly smaller than wild-type littermates
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endocrine/exocrine glands
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• smaller than in controls
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• retains vacuolated fetal zone X, which is absent in wild-type animals that progress through puberty
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• poorly developed
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• poorly developed
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• lacking in female mutants
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• late-stage antral follicles are absent
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• females have large number of atretic follicles compared to wild-type
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small ovary
(
J:122381
)
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• smaller than in controls
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• failure of Sertoli cell fluid secretion
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• testes weigh 28.4 mg compared to 215.1 mg in control males
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reproductive system
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• poorly developed
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• poorly developed
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• lacking in female mutants
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• late-stage antral follicles are absent
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• females have large number of atretic follicles compared to wild-type
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small ovary
(
J:122381
)
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• smaller than in controls
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• failure of Sertoli cell fluid secretion
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• testes weigh 28.4 mg compared to 215.1 mg in control males
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• uteri appear typical of those of mice before puberty with paucity of gland development and narrow endometrial layer
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small uterus
(
J:122381
)
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• uterus is thread-like in mutants relative to controls
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• uterus is 5.38 mg compared to 84.67 mg in wild-type controls
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• females fail to undergo normal vaginal opening at pubertal age
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• few spermatozoa are found in testes and these fail to exit into the lumen of the epididymis
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azoospermia
(
J:122381
)
|
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• males have absence of spermatozoa in most seminiferous tubules
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• spermiogenesis is incomplete
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small penis
(
J:122381
)
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• mice do not undergo pubertal sexual maturation
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anovulation
(
J:122381
)
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• failure of ovulation
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• females do not progress through the oestrous cycle
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homeostasis/metabolism
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• testosterone levels in male mutants are nearly undetectable (<0.17 pg/ml) compared to wild-type (4.1 pg/ml)
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• females do not show cyclic fluctuations in estradiol levels that are observed in wild-type females
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• females have (not significantly) lower 17-beta-estradiol levels at proestrus
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• mutants of both sexes have significantly lower plasma FSH levels compared to wild-type
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• plasma LH levels are lower in male mutants (0.28 ng/ml) compared to wild-type; however, mutants show a greater LH response to treatment with kisspeptin-10 than wild-type
• levels in females are lower (0.30 ng/ml) than wild-type proestrus mice (0.46 ng/ml) but not compared to oestrus or diestrus/metestrus females
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liver/biliary system
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• smaller than in controls
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renal/urinary system
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• poorly developed
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• smaller than in controls
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small penis
(
J:122381
)
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digestive/alimentary system
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• smaller than in controls
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integument
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• poorly developed
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| hypogonadotropic hypogonadism 13 with or without anosmia | DOID:0090073 |
OMIM:614842 |
J:122381 | |
