Phenotypes associated with this allele

• Allele Symbol: Card9^tm1Tks
• Allele Name: targeted mutation 1, Takashi Saito
• Allele ID: MGI:3715521
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Card9^tm1Tks/Card9^tm1Tks	B6.129-Card9^tm1Tks	MGI:3716873

Genotype
MGI:3716873

hm1

• Allelic Composition: Card9^tm1Tks/Card9^tm1Tks
• Genetic Background: B6.129-Card9^tm1Tks

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:122394 )

N • mice show normal T and B ccll development and activation

abnormal macrophage physiology ( J:122394 , J:141143 )

• after treatment with MAIR-II or TREM-1, production of Il-2. Il-12, Il-6, and TNF is abrogated in bone marrow derived macrophages (J:122394)

• bone marrow-derived macrophages fail to respond to Clec4e (Mincle) stimulation (J:141143)

abnormal dendritic cell physiology ( J:122394 )

• after Fc gamma crosslinking, bone marrow derived dendirtic cells show decreased production of Il-12, TNF and Il-6

• after stimulation with zymosan, bone marrow-derived dendritic cells produce much less TNF and Il-6, while Il-12 production is slightly lower

• after stimulation with NaClO-oxidized zymosan, cytokine responses are abolished in bone marrow-derived dendritic cells

• in response to Toll-like receptor ligands, production of TNF and Il-6 is much lower than in wild-type; TLR-induced TNF production without costimulation by TREM-1 antibodies is lower than in wild-type cells

abnormal cytokine secretion ( J:122394 )

abnormal chemokine secretion ( J:141143 )

• bone marrow-derived macrophages fail to secrete MIP-2 to Clec4e (Mincle) stimulation

decreased interleukin-10 secretion ( J:160680 )

• by BMDCs in response to Mannans and water-soluble mannans from Serotype A C. albicans

• by BMDCs stimulated by yeast or hyphae forms of C.albicans

decreased interleukin-12b secretion ( J:160680 )

• by BMDCs in response to Mannans and water-soluble mannans from Serotype A C. albicans

• by BMDCs stimulated by yeast or hyphae forms of C.albicans

decreased interleukin-23 secretion ( J:160680 )

• by BMDCs stimulated by yeast form of C.albicans

decreased interleukin-6 secretion ( J:160680 )

• by BMDCs in response to Mannans and water-soluble mannans from Serotype A C. albicans

• by BMDCs stimulated by yeast or hyphae forms of C.albicans

decreased tumor necrosis factor secretion ( J:160680 )

• by BMDCs in response to Mannans and water-soluble mannans from Serotype A C. albicans

• by BMDCs stimulated by yeast or hyphae forms of C.albicans

increased susceptibility to bacterial infection ( J:122394 )

• infection of mice with Listeria monocytogenes results in higher listerial burden in spleens and livers compared to wild-type mice

hematopoietic system

abnormal macrophage physiology ( J:122394 , J:141143 )

• after treatment with MAIR-II or TREM-1, production of Il-2. Il-12, Il-6, and TNF is abrogated in bone marrow derived macrophages (J:122394)

• bone marrow-derived macrophages fail to respond to Clec4e (Mincle) stimulation (J:141143)