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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ccn1tm2Lfl
targeted mutation 2, Lester F Lau
MGI:3715733
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ccn1tm2Lfl/Ccn1tm2Lfl involves: 129S4/SvJae MGI:5529805
hm2
 		Ccn1tm2Lfl/Ccn1tm2Lfl involves: 129S4/SvJae * C57BL/6 MGI:3715734


Genotype
MGI:5529805
hm1
Allelic
Composition		 Ccn1tm2Lfl/Ccn1tm2Lfl
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccn1tm2Lfl mutation (2 available); any Ccn1 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased susceptibility to injury ( J:204032 )
• CCl4-treated mice exhibit increased fibrosis and hydroxyproline content with reduced senescence compared with wild-type mice
• however, injection of the wild-type protein accelerates resolution of hepatic fibrosis




Genotype
MGI:3715734
hm2
Allelic
Composition		 Ccn1tm2Lfl/Ccn1tm2Lfl
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccn1tm2Lfl mutation (2 available); any Ccn1 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
decreased apoptosis ( J:119829 )
• concanavalin A-induced apoptosis is suppressed by greater than 60% in in vitro and in vivo assays




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory