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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Del(6Hoxa)1Ddu
deletion, Chr 6, Denis Duboule 1
MGI:3715855
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Del(2Hoxd10-Hoxd12)19Ddu/Del(2Hoxd10-Hoxd12)19Ddu
Hoxatm1Ddu/Del(6Hoxa)1Ddu
Tg(Prrx1-cre)1Cjt/0 		involves: 129S2/SvPas * C57BL/6J * SJL/J MGI:3715860
cn2
 		Del(2Hoxd8-Hoxd13)11Ddu/Del(2Hoxd8-Hoxd13)11Ddu
Hoxatm1Ddu/Del(6Hoxa)1Ddu
Tg(Prrx1-cre)1Cjt/0 		involves: 129S2/SvPas * C57BL/6J * SJL/J MGI:3715861
cn3
 		Del(2Hoxd9-Hoxd12)20Ddu/Del(2Hoxd9-Hoxd12)20Ddu
Hoxatm1Ddu/Del(6Hoxa)1Ddu
Tg(Prrx1-cre)1Cjt/0 		involves: 129S2/SvPas * C57BL/6J * SJL/J MGI:3715862
cn4
 		Del(2Hoxd11-Hoxd13)16Ddu/Del(2Hoxd11-Hoxd13)16Ddu
Hoxatm1Ddu/Del(6Hoxa)1Ddu
Tg(Prrx1-cre)1Cjt/0 		involves: 129S2/SvPas * C57BL/6J * SJL/J MGI:3715863
cn5
 		Del(2Hoxd10-Hoxd13)7Ddu/Del(2Hoxd10-Hoxd13)7Ddu
Hoxatm1Ddu/Del(6Hoxa)1Ddu
Tg(Prrx1-cre)1Cjt/0 		involves: 129S2/SvPas * C57BL/6 * SJL MGI:3715858


Genotype
MGI:3715860
cn1
Allelic
Composition		 Del(2Hoxd10-Hoxd12)19Ddu/Del(2Hoxd10-Hoxd12)19Ddu
Hoxatm1Ddu/Del(6Hoxa)1Ddu
Tg(Prrx1-cre)1Cjt/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(2Hoxd10-Hoxd12)19Ddu mutation (0 available); any Del(2Hoxd10-Hoxd12)19Ddu mutation (0 available)
Del(6Hoxa)1Ddu mutation (0 available); any Del(6Hoxa)1Ddu mutation (0 available)
Hoxatm1Ddu mutation (0 available); any Hoxa mutation (0 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
limbs/digits/tail phenotype ( J:114566 )
N
• when Hoxd13 is present, digits form on forelimb in newborn mice
abnormal forelimb zeugopod morphology ( J:114566 )
• clear forearm is observed; structure is ill-formed, reduced, and poorly ossified




Genotype
MGI:3715861
cn2
Allelic
Composition		 Del(2Hoxd8-Hoxd13)11Ddu/Del(2Hoxd8-Hoxd13)11Ddu
Hoxatm1Ddu/Del(6Hoxa)1Ddu
Tg(Prrx1-cre)1Cjt/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(2Hoxd8-Hoxd13)11Ddu mutation (0 available); any Del(2Hoxd8-Hoxd13)11Ddu mutation (0 available)
Del(6Hoxa)1Ddu mutation (0 available); any Del(6Hoxa)1Ddu mutation (0 available)
Hoxatm1Ddu mutation (0 available); any Hoxa mutation (0 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
abnormal forelimb zeugopod morphology ( J:114566 )
• no genuine forearm in newborn mice
abnormal limb development ( J:114566 )
• abnormal segmented cartilaginous condensation is present, instead of digits, radii, or ulnae
abnormal digit development ( J:114566 )
• no genuine digits form on forelimb in newborn mice

skeleton




Genotype
MGI:3715862
cn3
Allelic
Composition		 Del(2Hoxd9-Hoxd12)20Ddu/Del(2Hoxd9-Hoxd12)20Ddu
Hoxatm1Ddu/Del(6Hoxa)1Ddu
Tg(Prrx1-cre)1Cjt/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(2Hoxd9-Hoxd12)20Ddu mutation (0 available); any Del(2Hoxd9-Hoxd12)20Ddu mutation (0 available)
Del(6Hoxa)1Ddu mutation (0 available); any Del(6Hoxa)1Ddu mutation (0 available)
Hoxatm1Ddu mutation (0 available); any Hoxa mutation (0 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
limbs/digits/tail phenotype ( J:114566 )
N
• when Hoxd13 is present, digits form on forelimb in newborn mice
abnormal forelimb zeugopod morphology ( J:114566 )
• clear forearm is observed; structure is ill-formed, reduced, and poorly ossified




Genotype
MGI:3715863
cn4
Allelic
Composition		 Del(2Hoxd11-Hoxd13)16Ddu/Del(2Hoxd11-Hoxd13)16Ddu
Hoxatm1Ddu/Del(6Hoxa)1Ddu
Tg(Prrx1-cre)1Cjt/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6J * SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(2Hoxd11-Hoxd13)16Ddu mutation (0 available); any Del(2Hoxd11-Hoxd13)16Ddu mutation (0 available)
Del(6Hoxa)1Ddu mutation (0 available); any Del(6Hoxa)1Ddu mutation (0 available)
Hoxatm1Ddu mutation (0 available); any Hoxa mutation (0 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
abnormal forelimb zeugopod morphology ( J:114566 )
• presence of Hoxd10 leads to better-developed and ossified zeugopod
abnormal digit development ( J:114566 )
• only rod-like structures are present distally on forelimb in newborn mice




Genotype
MGI:3715858
cn5
Allelic
Composition		 Del(2Hoxd10-Hoxd13)7Ddu/Del(2Hoxd10-Hoxd13)7Ddu
Hoxatm1Ddu/Del(6Hoxa)1Ddu
Tg(Prrx1-cre)1Cjt/0
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(2Hoxd10-Hoxd13)7Ddu mutation (0 available); any Del(2Hoxd10-Hoxd13)7Ddu mutation (0 available)
Del(6Hoxa)1Ddu mutation (0 available); any Del(6Hoxa)1Ddu mutation (0 available)
Hoxatm1Ddu mutation (0 available); any Hoxa mutation (0 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
abnormal forelimb zeugopod morphology ( J:114566 )
• no genuine forearm in newborn mice
abnormal limb development ( J:114566 )
• abnormal segmented cartilaginous condensation is present, instead of digits, radii, or ulnae
abnormal digit development ( J:114566 )
• no genuine digits form on forelimb in newborn mice

skeleton




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11/12/2024
MGI 6.24 		The Jackson Laboratory