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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tmem38atm1Hta
targeted mutation 1, Hiroshi Takeshima
MGI:3716063
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tmem38atm1Hta/Tmem38atm1Hta involves: 129S4/SvJae MGI:3716684
cx2
 		Tmem38atm1Hta/Tmem38a+
Tmem38btm1Hta/Tmem38b+ 		involves: 129S4/SvJae MGI:3716686


Genotype
MGI:3716684
hm1
Allelic
Composition		 Tmem38atm1Hta/Tmem38atm1Hta
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem38atm1Hta mutation (0 available); any Tmem38a mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:122817 )
N
• mice are viable and fertile




Genotype
MGI:3716686
cx2
Allelic
Composition		 Tmem38atm1Hta/Tmem38a+
Tmem38btm1Hta/Tmem38b+
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tmem38atm1Hta mutation (0 available); any Tmem38a mutation (21 available)
Tmem38btm1Hta mutation (0 available); any Tmem38b mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:122817 )
• mice die beyond E10.5 due to cardiac defects

cardiovascular system
decreased myocardial fiber number ( J:122817 )
• cardiomyocyte viability is lost
abnormal fetal cardiomyocyte morphology ( J:122817 )
• at E8 to E9.5, looped cardiac tubes have irregular cytoplasmic vacuoles, and swollen sacroplasmic reticulum and endoplasmic reticulum
abnormal heartbeat ( J:122817 )
• at E9.5, mice have weak heartbeats
abnormal myocardial fiber physiology ( J:122817 )
• at E8.5, intracellular calcium oscillation is depressed
• caffeine-induced intracellular calcium signaling is enhanced

muscle
decreased myocardial fiber number ( J:122817 )
• cardiomyocyte viability is lost
abnormal muscle physiology ( J:122817 )
• intracellular calcium signaling in skeletal muscle is disturbed




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory