Phenotypes associated with this allele

• Allele Symbol: Pik3ca^tm1Jdo
• Allele Name: targeted mutation 1, Julian Downward
• Allele ID: MGI:3716068
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pik3ca^tm1Jdo/Pik3ca^tm1Jdo	B6.129S7(Cg)-Pik3ca^tm1Jdo	MGI:3716660
cx2	Kras^tm3Tyj/Kras^+ Pik3ca^tm1Jdo/Pik3ca^tm1Jdo	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J	MGI:3716661

Genotype
MGI:3716660

hm1

• Allelic Composition: Pik3ca^tm1Jdo/Pik3ca^tm1Jdo
• Genetic Background: B6.129S7(Cg)-Pik3ca^tm1Jdo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:122866 )

• some mice die during the first day after birth

postnatal lethality, incomplete penetrance ( J:122866 )

• some mice die prior to two weeks after birth

immune system

abnormal lymphatic vessel morphology ( J:122866 )

• at E18.5, intercostals vessels are absent and fewer vessels are found in the skin and diaphragm

abnormal lymphangiogenesis ( J:122866 )

• lymphatic vasculature is deficient in branching and development of the network

homeostasis/metabolism

chylous ascites ( J:122866 )

• most mice have a milky appearance of the peritoneum

decreased incidence of tumors by chemical induction ( J:122866 )

• following DMBA (7,12-dimethylbenzanthracene) and TPA (12-O-tetradecanoylphorbol-13-acetate), no incidents of skin tumors occur as they do in wild-type mice

neoplasm

decreased incidence of tumors by chemical induction ( J:122866 )

• following DMBA (7,12-dimethylbenzanthracene) and TPA (12-O-tetradecanoylphorbol-13-acetate), no incidents of skin tumors occur as they do in wild-type mice

growth/size/body

decreased body weight ( J:122866 )

• the weight of mice surviving into adulthood is decreased compared to wild-type mice

Genotype
MGI:3716661

cx2

• Allelic Composition: Kras^tm3Tyj/Kras⁺; Pik3ca^tm1Jdo/Pik3ca^tm1Jdo
• Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J

neoplasm

decreased incidence of induced tumors ( J:122866 )

• zero to two visible tumors are found compared to forty or so tumors in Kras^tm3Tyj mice

• apoptotic rates in small lesions are increased compared to in Kras^tm3Tyj mice

decreased lung tumor incidence ( J:122866 )

• one mouse did not show any evidence of lung tumor formation up to 6 months of age

respiratory system

decreased lung tumor incidence ( J:122866 )

• one mouse did not show any evidence of lung tumor formation up to 6 months of age