Phenotypes associated with this allele

• Allele Symbol: Tg(AMELX*P70T)2Gibs
• Allele Name: transgene insertion 2, Carolyn Gibson
• Allele ID: MGI:3716166
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Amelx^tm1Kul/Amelx^tm1Kul Tg(AMELX*P70T)2Gibs/?	involves: 129S1/Sv * 129X1/SvJ	MGI:5086118
tg2	Tg(AMELX*P70T)2Gibs/?	Not Specified	MGI:5086116

Genotype
MGI:5086118

cx1

• Allelic Composition: Amelx^tm1Kul/Amelx^tm1Kul; Tg(AMELX*P70T)2Gibs/?
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor incidence ( J:122914 )

♀ • molar enamel has a hyperplastic intermedium cell layer exhibiting transition to tumor cells

♀ • tumor is composed of benign, eosinophilic, polygonal-shaped cells with intercellular bridges

♀ • calcification is not obvious in these tumors

craniofacial

abnormal enamel morphology ( J:122914 )

♀ • molar enamel has a hyperplastic intermedium cell layer exhibiting transition to tumor cells

growth/size/body

abnormal enamel morphology ( J:122914 )

♀ • molar enamel has a hyperplastic intermedium cell layer exhibiting transition to tumor cells

skeleton

abnormal enamel morphology ( J:122914 )

♀ • molar enamel has a hyperplastic intermedium cell layer exhibiting transition to tumor cells

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
amelogenesis imperfecta type 1E		DOID:0110058	OMIM:301200	J:122914

Genotype
MGI:5086116

tg2

• Allelic Composition: Tg(AMELX*P70T)2Gibs/?
• Genetic Background: Not Specified

craniofacial

abnormal molar morphology ( J:122914 )

• molars have irregular chalky appearance

abnormal molar cusp morphology ( J:122914 )

• molars show marked attrition of cusps

abnormal enamel rod pattern ( J:122914 )

• molar enamel has aprismatic regions with the porosity and appearance of platelike crystallites

• males exhibit more aprismatic regions than females

abnormal tooth attrition ( J:122914 )

• molars show marked attrition of cusps

growth/size/body

abnormal molar morphology ( J:122914 )

• molars have irregular chalky appearance

abnormal molar cusp morphology ( J:122914 )

• molars show marked attrition of cusps

abnormal enamel rod pattern ( J:122914 )

• molar enamel has aprismatic regions with the porosity and appearance of platelike crystallites

• males exhibit more aprismatic regions than females

abnormal tooth attrition ( J:122914 )

• molars show marked attrition of cusps

skeleton

abnormal molar morphology ( J:122914 )

• molars have irregular chalky appearance

abnormal molar cusp morphology ( J:122914 )

• molars show marked attrition of cusps

abnormal enamel rod pattern ( J:122914 )

• molar enamel has aprismatic regions with the porosity and appearance of platelike crystallites

• males exhibit more aprismatic regions than females

abnormal tooth attrition ( J:122914 )

• molars show marked attrition of cusps

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
amelogenesis imperfecta type 1E		DOID:0110058	OMIM:301200	J:122914