Phenotypes associated with this allele

• Allele Symbol: Magi2^tm1Yhat
• Allele Name: targeted mutation 1, Yutaka Hata
• Allele ID: MGI:3716218
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Magi2^tm1Yhat/Magi2^tm1Yhat	involves: 129S/SvEv * C57BL/6 * DBA/2	MGI:3716616

Genotype
MGI:3716616

hm1

• Allelic Composition: Magi2^tm1Yhat/Magi2^tm1Yhat
• Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:122354 )

• neonatal mice die within 24 hours of birth

nervous system

abnormal neuron morphology ( J:122354 )

• dendritic spines of hippocampal neurons are more elongated compared to wild-type mice; this can be rescued with reintroduction of Magi2 into neurons

• filopodia density of neurons is larger in mutant mice (13.4 filopodia per 30 um vs 8.3 in wild-type neurons)

• mutant dendritic spines do not retract in neuronal cultures treated with NMDA, in contrast to treated wild-type neurons