Phenotypes associated with this allele

• Allele Symbol: Ucn^tm1Abas
• Allele Name: targeted mutation 1, Abdul Abou-Samra
• Allele ID: MGI:3716279
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ucn^tm1Abas/Ucn^tm1Abas	B6.129S4-Ucn^tm1Abas	MGI:3716565

Genotype
MGI:3716565

hm1

• Allelic Composition: Ucn^tm1Abas/Ucn^tm1Abas
• Genetic Background: B6.129S4-Ucn^tm1Abas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal emotion/affect behavior ( J:122730 )

• male mutant mice do not show adaptation to stress with repeated restraint, in contrast to wild-type controls

• neither male or female mutant mice show a corticosterone response to 2-hour cold exposure

homeostasis/metabolism

abnormal circulating corticosterone level ( J:122730 )

• unlike wild-type animals, males and females do not show any corticosterone response to cold exposure

• males show no corticosterone response to cold exposure when they are subjected to repeated restraint, in contrast to response to restraint alone; female mutants show significant corticosterone response after repeated restraint

• male and female mutant mice have similar basal corticosterone levels, whereas wild-type males show higher levels than females

• neither male or female mutant mice show a corticosterone response to 2-hour cold exposure

increased circulating corticosterone level ( J:122730 )

• basal level in blood of males is higher (188.1 ng/ml) than in wild-type controls (65.6 ng/ml)

• levels after 15 minutes of restraint rise to 274 ng/ml in mutants vs 215 ng/ml in wild-type; with repeated restraint, levels in wild-type fall to 142 ng/ml, but continue to increase in mutant mice to 480 ng/ml