mortality/aging
• homozygotes can be recovered at E9.5, but embryos are severely abnormal
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embryo
• embryos appear grossly disorganized at E9.5
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• embryos fail to initiate ventral folding
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• at E9.5, embryos are dramatically growth retarded
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growth/size/body
• at E9.5, embryos are dramatically growth retarded
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cardiovascular system
• embryos do not initiate ventral folding, a prerequistite for heart formation
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