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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Usp8tm1.2Kpk
targeted mutation 1.2, Klaus-Peter Knobeloch
MGI:3716285
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Usp8tm1.2Kpk/Usp8tm1.2Kpk involves: 129P2/OlaHsd * FVB/N MGI:3716595


Genotype
MGI:3716595
hm1
Allelic
Composition		 Usp8tm1.2Kpk/Usp8tm1.2Kpk
Genetic
Background		 involves: 129P2/OlaHsd * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Usp8tm1.2Kpk mutation (0 available); any Usp8 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:122732 )
• homozygotes can be recovered at E9.5, but embryos are severely abnormal

embryo
abnormal embryo development ( J:122732 )
• embryos appear grossly disorganized at E9.5
abnormal dorsal-ventral axis patterning ( J:122732 )
• embryos fail to initiate ventral folding
embryonic growth retardation ( J:122732 )
• at E9.5, embryos are dramatically growth retarded

growth/size/body
embryonic growth retardation ( J:122732 )
• at E9.5, embryos are dramatically growth retarded

cardiovascular system
abnormal heart development ( J:122732 )
• embryos do not initiate ventral folding, a prerequistite for heart formation




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory