Analysis Tools
mortality/aging
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• 20% of expected mice are missing at week 4 although Mendelian ratios are born
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skeleton
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• as early as E14.5, ossification is delayed especially in the parietal and frontal bones of the calvaria and in the maxillary and mandibular components of the facial skeleton
• at E16.5, delays in ossification are more prominent in the skull
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• at 2 months, the coronal suture is V-shaped and irregular
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• at P0, the metopic (interfrontal) suture is widened
• at 2 months, the posterior part of the metopic suture is still unossified (open)
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• at 2 months, sagittal suture is shortened
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• at P0, the frontal, parietal and interparietal bones are reduced in size, the anterior and posterior fontanelles are enlarged and the sagittal and metopic sutures are wide
• proliferation of osteoprogenitors is reduced in calvaria bones
• osteogenesis in calvaria bones is perturbed
• bone nodule formation in calvaria is defective
• at 5.5 months, the vault of the skull is shortened and rounded
• fewer (pre)osteoblasts are present in calvaria bones
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• newborns display an enlarged anterior fontanelle
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• newborns display an enlarged posterior fontanelle
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• at 2 months
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• at 3 weeks
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• at E16.5, delays in ossification are more prominent in the bony collar surrounding the long bones of the appendicular skeleton
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• long bones are 12 to 23% shorter than in wild-type mice
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• fusion of the pubis and ischial bone is delayed
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• at 5.5 months, the processus spinosus is poorly ossified
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• at 2 months, vertebral arches are not fused
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• fewer (pre)osteoblasts are present in calvaria bones
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• osteogenesis in calvaria bones is perturbed
• bone nodule formation in calvaria is defective
|
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• as early as E14.5, ossification is delayed especially in the parietal and frontal bones of the calvaria and in the maxillary and mandibular components of the facial skeleton
• at E16.5, delays in ossification are more prominent in the skull and in the bony collar surrounding the long bones of the appendicular skeleton
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growth/size/body
broad snout
(
J:122741
)
|
• at 3 weeks, mice have short and broad snouts
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short snout
(
J:122741
)
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• at 3 weeks, mice have short and broad snouts
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• mice are slightly smaller at birth than wild-type mice and the size disparity increases progressively with postnatally
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• at P14, mice weigh 20 to 50% less than wild-type mice
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• at P14, mice are 5 to 10% shorter than wild-type mice
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vision/eye
exophthalmos
(
J:122741
)
|
• at 3 weeks
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craniofacial
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• as early as E14.5, ossification is delayed especially in the parietal and frontal bones of the calvaria and in the maxillary and mandibular components of the facial skeleton
• at E16.5, delays in ossification are more prominent in the skull
|
|
• at 2 months, the coronal suture is V-shaped and irregular
|
|
• at P0, the metopic (interfrontal) suture is widened
• at 2 months, the posterior part of the metopic suture is still unossified (open)
|
|
• at 2 months, sagittal suture is shortened
|
|
• at P0, the frontal, parietal and interparietal bones are reduced in size, the anterior and posterior fontanelles are enlarged and the sagittal and metopic sutures are wide
• proliferation of osteoprogenitors is reduced in calvaria bones
• osteogenesis in calvaria bones is perturbed
• bone nodule formation in calvaria is defective
• at 5.5 months, the vault of the skull is shortened and rounded
• fewer (pre)osteoblasts are present in calvaria bones
|
|
• newborns display an enlarged anterior fontanelle
|
|
• newborns display an enlarged posterior fontanelle
|
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• at 2 months
|
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• at 3 weeks
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broad snout
(
J:122741
)
|
• at 3 weeks, mice have short and broad snouts
|
short snout
(
J:122741
)
|
• at 3 weeks, mice have short and broad snouts
|
