Phenotypes associated with this allele

• Allele Symbol: Trpm8^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:3716553
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trpm8^tm1Lex/Trpm8^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6	MGI:3717467

Genotype
MGI:3717467

hm1

• Allelic Composition: Trpm8^tm1Lex/Trpm8^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal thermosensation ( J:122956 )

• mice show no floor temperature preference between room temperature and 5 degrees Celsius unlike wild-type mice

• mice prefer a 5 degree Celsius floor plate versus a 45 degree Celsius one, while wild-type mice show the opposite preference

abnormal nociception after inflammation ( J:122956 )

• following induction of subchronic inflammation mice show reduced responses to plantar acetone application compared to controls

abnormal pain threshold ( J:122956 )

• following sciatic ligation mice do not display any increase in acetone sensitivity unlike wild-type mice

increased thermal nociceptive threshold ( J:122956 )

• mice do not jump in response to icilin exposure

nervous system

abnormal neuron physiology ( J:122956 )

• decrease in the number of menthol-senstive (by 77%) and cold-sensitive (by 40%) trigeminal ganglion neurons compared to wild-type mice