Phenotypes associated with this allele

• Allele Symbol: Trpm8^tm1Apat
• Allele Name: targeted mutation 1, Ardem Patapoutian
• Allele ID: MGI:3716558
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trpm8^tm1Apat/Trpm8^tm1Apat	involves: 129S1/Sv * C57BL/6	MGI:3717468

Genotype
MGI:3717468

hm1

• Allelic Composition: Trpm8^tm1Apat/Trpm8^tm1Apat
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal thermosensation ( J:122963 )

• presented with a floor temperature gradient mice spend more time in the cooler areas (23 - 30 C) and less time in warm areas (30 - 38 C) compared to wild-type mice

• mice show no preference for a floor at 31 C over one at 18 C unlike wild-type mice

• response of mice to the cooling effect of acetone is significantly reduced

abnormal nociception after inflammation ( J:122963 )

• absence of cold-induced analgesic response following formalin injection

increased thermal nociceptive threshold ( J:122963 )

• following icilin injection mice do not display hindpaw withdrawal on a 1 C plate or wet-dog shakes

• however, cold nociception response to sub-zero temperatures is normal

nervous system

abnormal neuron physiology ( J:122963 )

• only 7.6% of cultured dorsal root ganglion neurons respond to a cold stimulus compared to 14.9% of wild-type neurons