Phenotypes associated with this allele

• Allele Symbol: Ntrk2^tm2Lfr
• Allele Name: targeted mutation 2, Louis F Reichardt
• Allele ID: MGI:3716645
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ntrk2^tm2Lfr/Ntrk2^tm2Lfr Tg(Six3-cre)69Frty/? Tg(Thy1-YFP)HJrs/?	involves: C57BL/6 * CBA * DBA/2	MGI:3717378

Genotype
MGI:3717378

cn1

• Allelic Composition: Ntrk2^tm2Lfr/Ntrk2^tm2Lfr; Tg(Six3-cre)69Frty/?; Tg(Thy1-YFP)HJrs/?
• Genetic Background: involves: C57BL/6 * CBA * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal retina ganglion cell morphology ( J:122929 )

• at P28, mice have a greater percent of ON-OFF retinal ganglion cells (RGCs) than in control mice

• at P28, mice have fewer ON and OFF RGCs than controls

• at P28, mice have fewer numbers of ON RGC dendritic branches

• at P50, 55.4+/-4.3% of RGCs are bilaminated compared to 37.8+/-1.1% in controls

nervous system

abnormal dendrite morphology ( J:122929 )

• at P28, mice have fewer numbers of ON retinal ganglion cells (RGCs) dendritic branches

abnormal retina ganglion cell morphology ( J:122929 )

• at P28, mice have a greater percent of ON-OFF retinal ganglion cells (RGCs) than in control mice

• at P28, mice have fewer ON and OFF RGCs than controls

• at P28, mice have fewer numbers of ON RGC dendritic branches

• at P50, 55.4+/-4.3% of RGCs are bilaminated compared to 37.8+/-1.1% in controls