Analysis Tools
mortality/aging
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• mice fed a high fat diet experience premature lethality after 20 weeks relative to the survival of wild-type mice on a high fat diet
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• fewer than expected mice survive to weaning
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homeostasis/metabolism
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• VLDL production is decreased
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• following 20 weeks on a high fat diet, moribund mice have abdominal distention consistent with chylous ascites
• 6 of 15 mice fed a high fat Western diet and injected with 14D12 antibodies for 15 weeks develop chylous ascites
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• fasting triglyceride levels are lower than in wild-type mice when maintained on normal chow or a high fat diet
• following intragastric loading of olive oil, mice have lower triglyceride levels than wild-type mice similarly treated
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• triglyceride levels are significantly lower between 6 and 22 weeks of age
• these levels are also lower when mice are fed a high fat diet
• triglyceride levels are also lower than those found in heterozygote controls
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• following intragastric loading of olive oil
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digestive/alimentary system
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• muscosa in moribund mice is thickened with mild to moderate infiltration of foamy macrophages in the lamina propria
• following 20 weeks on a high fat diet, mice exhibit milder and more chronic lipogranulomatous inflammation in the lamina propria of the small intestine
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immune system
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• following 20 weeks on a high fat diet, mice exhibit lipogranulomatous inflammation primarily affecting the lymphatic vessels and mesenteric lymph nodes in which lymphatics become fibrotic and dilated
• 13 of 15 mice fed a high fat Western diet and injected with 14D12 antibodies for 15 weeks exhibit lipogranulomatous inflammation of the lymphatic vessels and mesenteric lymph nodes
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• lymphatics and lacteals are frequently dilated in moribund mice
• following 20 weeks on a high fat diet, mice exhibit lipogranulomatous inflammation primarily affecting the lymphatic vessels and mesenteric lymph nodes in which lymphatics become fibrotic and dilated
• 13 of 15 mice fed a high fat Western diet and injected with 14D12 antibodies for 15 weeks exhibit lipogranulomatous inflammation of the lymphatic vessels and mesenteric lymph nodes
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