Phenotypes associated with this allele

• Allele Symbol: Gsc^tm2Bhr
• Allele Name: targeted mutation 2, Richard R Behringer
• Allele ID: MGI:3716759
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Dkk1^tm1Lmgd/Dkk1^+ Gsc^tm2Bhr/Gsc^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3716765
cx2	Dkk1^tm1Lmgd/Dkk1^+ Gsc^tm2Bhr/Gsc^tm2Bhr	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3716766

Genotype
MGI:3716765

cx1

• Allelic Composition: Dkk1^tm1Lmgd/Dkk1⁺; Gsc^tm2Bhr/Gsc⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

decreased forebrain size ( J:119933 )

• about 43% of embryos at E7.5 - E9.5 display a mild reduction in forebrain size

Genotype
MGI:3716766

cx2

• Allelic Composition: Dkk1^tm1Lmgd/Dkk1⁺; Gsc^tm2Bhr/Gsc^tm2Bhr
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

embryo

abnormal embryo development ( J:119933 )

• about 75% of embryos at E7.5 - E9.5 display abnormalities that vary in severity

nervous system

decreased forebrain size ( J:119933 )

• at E8.5 and E9.5 variable truncations of the forebrain are seen ranging from mild reduction in head size (14.3% of embryos) to partial loss of the forebrain and ill-defined brain segments (42.8%) and in severely affected embryos (14.3%) anterior truncations resembling those in Dkk1 single homozygotes

vision/eye

abnormal eye development ( J:119933 )

• poor development of the eye primordium in moderately affected embryos (42.8%)

growth/size/body

microcephaly ( J:119933 )

• at E8.5 - E9.5, head size is reduced by 16% compared to wild-type