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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Shc1tm3Paw
targeted mutation 3, Tony Pawson
MGI:3716777
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Shc1tm3Paw/Shc1tm3Paw involves: 129S1/Sv * 129X1/SvJ MGI:3717090
ht2
 		Shc1tm3Paw/Shc1tm7Paw involves: 129S1/Sv * 129X1/SvJ MGI:3717108
ht3
 		Shc1tm3Paw/Shc1tm4Paw involves: 129S1/Sv * 129X1/SvJ MGI:3717109
cn4
 		Myl1tm1(cre)Sjb/Myl1+
Shc1tm3Paw/Shc1tm9Paw 		involves: 129S1/Sv * 129X1/SvJ MGI:3717104


Genotype
MGI:3717090
hm1
Allelic
Composition		 Shc1tm3Paw/Shc1tm3Paw
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shc1tm3Paw mutation (0 available); any Shc1 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:122927 )
• number of viable progeny is reduced to 12.2% compared to 25% expected




Genotype
MGI:3717108
ht2
Allelic
Composition		 Shc1tm3Paw/Shc1tm7Paw
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shc1tm3Paw mutation (0 available); any Shc1 mutation (66 available)
Shc1tm7Paw mutation (0 available); any Shc1 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal locomotor coordination ( J:122927 )
• mice display motor defects more severe than than transheterozygous Shc1tm3Paw/tm4Paw mice

nervous system
decreased muscle spindle number ( J:122927 )
• between P22 and P35, muscle spindles are abnormal and numbers are 13% of controls
• intrafusal fiber numbers are 35.9% of control numbers

muscle
decreased muscle spindle number ( J:122927 )
• between P22 and P35, muscle spindles are abnormal and numbers are 13% of controls
• intrafusal fiber numbers are 35.9% of control numbers




Genotype
MGI:3717109
ht3
Allelic
Composition		 Shc1tm3Paw/Shc1tm4Paw
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shc1tm3Paw mutation (0 available); any Shc1 mutation (66 available)
Shc1tm4Paw mutation (0 available); any Shc1 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal locomotor coordination ( J:122927 )
• mice display more severe motor defects than transheterozygous Shc1tm4Paw/tm7Paw mice

nervous system
decreased muscle spindle number ( J:122927 )
• between P22 and P35, muscle spindles are abnormal and numbers are 83.3% of controls
• intrafusal fiber numbers are 66.6% of control numbers

muscle
decreased muscle spindle number ( J:122927 )
• between P22 and P35, muscle spindles are abnormal and numbers are 83.3% of controls
• intrafusal fiber numbers are 66.6% of control numbers




Genotype
MGI:3717104
cn4
Allelic
Composition		 Myl1tm1(cre)Sjb/Myl1+
Shc1tm3Paw/Shc1tm9Paw
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myl1tm1(cre)Sjb mutation (2 available); any Myl1 mutation (17 available)
Shc1tm3Paw mutation (0 available); any Shc1 mutation (66 available)
Shc1tm9Paw mutation (0 available); any Shc1 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal locomotor coordination ( J:122927 )
• motor abnormalities are similar to those observed in Shc1tm7Paw homozygotes

nervous system
decreased muscle spindle number ( J:122927 )
• between P22 and P35, muscle spindle and intrafusal fiber numbers are reduced compared to controls

muscle
decreased muscle spindle number ( J:122927 )
• between P22 and P35, muscle spindle and intrafusal fiber numbers are reduced compared to controls




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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory