All Phenotypes Shc1<tm4Paw> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Shc1^tm4Paw
targeted mutation 4, Tony Pawson
MGI:3716778

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Shc1^tm4Paw/Shc1^tm4Paw	involves: 129S1/Sv * 129X1/SvJ	MGI:3717009
ht2	Shc1^tm3Paw/Shc1^tm4Paw	involves: 129S1/Sv * 129X1/SvJ	MGI:3717109
cn3	Myl1^tm1(cre)Sjb/Myl1⁺ Shc1^tm4Paw/Shc1^tm9Paw	involves: 129S1/Sv * 129X1/SvJ	MGI:3717105

Allelic Composition	Shc1^tm4Paw/Shc1^tm4Paw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shc1^tm4Paw mutation (0 available); any Shc1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:122927 )

• many embryos are dead at E11.5 (13/27), and no live embryos are found at E12.5

behavior/neurological

ataxia ( J:122927 )

• mice display less severe ataxia than Shc1^tm7Paw

nervous system

abnormal muscle spindle morphology ( J:122927 )

• total spindle numbers are normal but in mice at P2-P9 and in adults, intrafusal fiber numbers are 66.7 and 62.5% of contols numbers

abnormal nerve conduction ( J:122927 )

• synaptic conductivity of group Ia sensory neurons is impaired

abnormal excitatory postsynaptic potential ( J:122927 )

• amplitudes of short-latency EPSPs are smaller than in wild-type mice

muscle

abnormal myocardial trabeculae morphology ( J:122927 )

• cardiac trabeculae are poorly developed

abnormal muscle spindle morphology ( J:122927 )

• total spindle numbers are normal but in mice at P2-P9 and in adults, intrafusal fiber numbers are 66.7 and 62.5% of contols numbers

cardiovascular system

abnormal myocardial trabeculae morphology ( J:122927 )

• cardiac trabeculae are poorly developed

abnormal cardiovascular system physiology ( J:122927 )

• at E11.5, living embryos have irregularly beating hearts

Allelic Composition	Shc1^tm3Paw/Shc1^tm4Paw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shc1^tm3Paw mutation (0 available); any Shc1 mutation (66 available)
Shc1^tm4Paw mutation (0 available); any Shc1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal locomotor coordination ( J:122927 )

• mice display more severe motor defects than transheterozygous Shc1^{tm4Paw/tm7Paw} mice

nervous system

decreased muscle spindle number ( J:122927 )

• between P22 and P35, muscle spindles are abnormal and numbers are 83.3% of controls

• intrafusal fiber numbers are 66.6% of control numbers

muscle

decreased muscle spindle number ( J:122927 )

• between P22 and P35, muscle spindles are abnormal and numbers are 83.3% of controls

• intrafusal fiber numbers are 66.6% of control numbers

Allelic Composition	Myl1^tm1(cre)Sjb/Myl1⁺ Shc1^tm4Paw/Shc1^tm9Paw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myl1^tm1(cre)Sjb mutation (2 available); any Myl1 mutation (17 available)
Shc1^tm4Paw mutation (0 available); any Shc1 mutation (66 available)
Shc1^tm9Paw mutation (0 available); any Shc1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal locomotor coordination ( J:122927 )

• motor abnormalities are less severe, similar to those observed in Shc1^tm4Paw homozygotes

ataxia ( J:122927 )

muscle

abnormal muscle spindle morphology ( J:122927 )

• between P22 and P35, intrafusal fiber numbers are reduced compared to controls

nervous system

abnormal muscle spindle morphology ( J:122927 )

• between P22 and P35, intrafusal fiber numbers are reduced compared to controls

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