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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Shc1tm6Paw
targeted mutation 6, Tony Pawson
MGI:3716780
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Shc1tm6Paw/Shc1tm6Paw involves: 129S1/Sv * 129X1/SvJ MGI:3717093
cx2
Shc1tm6Paw/Shc1+
Tg(MMTV-PyVT)634Mul/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N MGI:4361927
cx3
Shc1tm6Paw/Shc1tm6Paw
Tg(MMTV-PyVT)634Mul/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N MGI:4361930


Genotype
MGI:3717093
hm1
Allelic
Composition
Shc1tm6Paw/Shc1tm6Paw
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shc1tm6Paw mutation (0 available); any Shc1 mutation (66 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• number of viable progeny is reduced to 17.5% (40/251) compared to 25% expected




Genotype
MGI:4361927
cx2
Allelic
Composition
Shc1tm6Paw/Shc1+
Tg(MMTV-PyVT)634Mul/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shc1tm6Paw mutation (0 available); any Shc1 mutation (66 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• tumor nodules are present throughout the entire mammary gland
• combination of adenomas and cystic hyperplasias are seen in mammary glands
• tumor angiogenesis assessed by microvessel density is significantly decreaed relative to tumors from Tg(MMTV-PyVT)634Mul single mutants, along with increased level of ischemic necrosis
• number of mice displaying lung metastases is decreased compared to Tg(MMTV-PyVT)634Mul single mutants (58 vs 91 mice)
• mammary tumor onset is modestly delayed compared to Tg(MMTV-PyVT)634Mul single mutants (86 days vs 66 days)

endocrine/exocrine glands
• tumor nodules are present throughout the entire mammary gland
• combination of adenomas and cystic hyperplasias are seen in mammary glands
• tumor nodules are present throughout the entire mammary gland
• combination of adenomas and cystic hyperplasias are seen in mammary glands
• tumor angiogenesis assessed by microvessel density is significantly decreaed relative to tumors from Tg(MMTV-PyVT)634Mul single mutants, along with increased level of ischemic necrosis

integument
• tumor nodules are present throughout the entire mammary gland
• combination of adenomas and cystic hyperplasias are seen in mammary glands
• tumor nodules are present throughout the entire mammary gland
• combination of adenomas and cystic hyperplasias are seen in mammary glands
• tumor angiogenesis assessed by microvessel density is significantly decreaed relative to tumors from Tg(MMTV-PyVT)634Mul single mutants, along with increased level of ischemic necrosis




Genotype
MGI:4361930
cx3
Allelic
Composition
Shc1tm6Paw/Shc1tm6Paw
Tg(MMTV-PyVT)634Mul/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shc1tm6Paw mutation (0 available); any Shc1 mutation (66 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• tumor nodules are present throughout the entire mammary gland
• lesions eventually progress to carcinoma
• tumors are highly apoptotic compared to tumors from Tg(MMTV-PyVT)634Mul single mutants
• tumor angiogenesis is decreased relative to tumors from Tg(MMTV-PyVT)634Mul single mutants
• number of mice displaying lung metastases is decreased about 3-fold compared to Tg(MMTV-PyVT)634Mul single mutants (30 vs 91 mice)
• mammary tumor latency is strongly increased compared to Tg(MMTV-PyVT)634Mul single mutants (132 days vs 66 days)

endocrine/exocrine glands
• entire gland is hyperplastic
• mammary glands are composed of single layer of epithelial cells surrounding a dilated lumen
• tumor nodules are present throughout the entire mammary gland
• lesions eventually progress to carcinoma
• tumors are highly apoptotic compared to tumors from Tg(MMTV-PyVT)634Mul single mutants
• tumor angiogenesis is decreased relative to tumors from Tg(MMTV-PyVT)634Mul single mutants

integument
• entire gland is hyperplastic
• mammary glands are composed of single layer of epithelial cells surrounding a dilated lumen
• tumor nodules are present throughout the entire mammary gland
• lesions eventually progress to carcinoma
• tumors are highly apoptotic compared to tumors from Tg(MMTV-PyVT)634Mul single mutants
• tumor angiogenesis is decreased relative to tumors from Tg(MMTV-PyVT)634Mul single mutants





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory