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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Shc1tm6Paw
targeted mutation 6, Tony Pawson
MGI:3716780
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Shc1tm6Paw/Shc1tm6Paw involves: 129S1/Sv * 129X1/SvJ MGI:3717093
cx2
 		Shc1tm6Paw/Shc1+
Tg(MMTV-PyVT)634Mul/0 		involves: 129S1/Sv * 129X1/SvJ * FVB/N MGI:4361927
cx3
 		Shc1tm6Paw/Shc1tm6Paw
Tg(MMTV-PyVT)634Mul/0 		involves: 129S1/Sv * 129X1/SvJ * FVB/N MGI:4361930


Genotype
MGI:3717093
hm1
Allelic
Composition		 Shc1tm6Paw/Shc1tm6Paw
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shc1tm6Paw mutation (0 available); any Shc1 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:122927 )
• number of viable progeny is reduced to 17.5% (40/251) compared to 25% expected




Genotype
MGI:4361927
cx2
Allelic
Composition		 Shc1tm6Paw/Shc1+
Tg(MMTV-PyVT)634Mul/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shc1tm6Paw mutation (0 available); any Shc1 mutation (66 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:133325 )
• tumor nodules are present throughout the entire mammary gland
• combination of adenomas and cystic hyperplasias are seen in mammary glands
• tumor angiogenesis assessed by microvessel density is significantly decreaed relative to tumors from Tg(MMTV-PyVT)634Mul single mutants, along with increased level of ischemic necrosis
decreased metastatic potential ( J:133325 )
• number of mice displaying lung metastases is decreased compared to Tg(MMTV-PyVT)634Mul single mutants (58 vs 91 mice)
increased tumor latency ( J:133325 )
• mammary tumor onset is modestly delayed compared to Tg(MMTV-PyVT)634Mul single mutants (86 days vs 66 days)

endocrine/exocrine glands
abnormal mammary gland morphology ( J:133325 )
• tumor nodules are present throughout the entire mammary gland
• combination of adenomas and cystic hyperplasias are seen in mammary glands
increased mammary gland tumor incidence ( J:133325 )
• tumor nodules are present throughout the entire mammary gland
• combination of adenomas and cystic hyperplasias are seen in mammary glands
• tumor angiogenesis assessed by microvessel density is significantly decreaed relative to tumors from Tg(MMTV-PyVT)634Mul single mutants, along with increased level of ischemic necrosis

integument
abnormal mammary gland morphology ( J:133325 )
• tumor nodules are present throughout the entire mammary gland
• combination of adenomas and cystic hyperplasias are seen in mammary glands
increased mammary gland tumor incidence ( J:133325 )
• tumor nodules are present throughout the entire mammary gland
• combination of adenomas and cystic hyperplasias are seen in mammary glands
• tumor angiogenesis assessed by microvessel density is significantly decreaed relative to tumors from Tg(MMTV-PyVT)634Mul single mutants, along with increased level of ischemic necrosis




Genotype
MGI:4361930
cx3
Allelic
Composition		 Shc1tm6Paw/Shc1tm6Paw
Tg(MMTV-PyVT)634Mul/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shc1tm6Paw mutation (0 available); any Shc1 mutation (66 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:133325 )
• tumor nodules are present throughout the entire mammary gland
• lesions eventually progress to carcinoma
• tumors are highly apoptotic compared to tumors from Tg(MMTV-PyVT)634Mul single mutants
• tumor angiogenesis is decreased relative to tumors from Tg(MMTV-PyVT)634Mul single mutants
decreased metastatic potential ( J:133325 )
• number of mice displaying lung metastases is decreased about 3-fold compared to Tg(MMTV-PyVT)634Mul single mutants (30 vs 91 mice)
increased tumor latency ( J:133325 )
• mammary tumor latency is strongly increased compared to Tg(MMTV-PyVT)634Mul single mutants (132 days vs 66 days)

endocrine/exocrine glands
abnormal mammary gland morphology ( J:133325 )
• entire gland is hyperplastic
• mammary glands are composed of single layer of epithelial cells surrounding a dilated lumen
increased mammary gland tumor incidence ( J:133325 )
• tumor nodules are present throughout the entire mammary gland
• lesions eventually progress to carcinoma
• tumors are highly apoptotic compared to tumors from Tg(MMTV-PyVT)634Mul single mutants
• tumor angiogenesis is decreased relative to tumors from Tg(MMTV-PyVT)634Mul single mutants

integument
abnormal mammary gland morphology ( J:133325 )
• entire gland is hyperplastic
• mammary glands are composed of single layer of epithelial cells surrounding a dilated lumen
increased mammary gland tumor incidence ( J:133325 )
• tumor nodules are present throughout the entire mammary gland
• lesions eventually progress to carcinoma
• tumors are highly apoptotic compared to tumors from Tg(MMTV-PyVT)634Mul single mutants
• tumor angiogenesis is decreased relative to tumors from Tg(MMTV-PyVT)634Mul single mutants




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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11/12/2024
MGI 6.24 		The Jackson Laboratory