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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Shc1tm7Paw
targeted mutation 7, Tony Pawson
MGI:3716781
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Shc1tm7Paw/Shc1tm7Paw involves: 129S1/Sv * 129X1/SvJ MGI:3717094
ht2
 		Shc1tm3Paw/Shc1tm7Paw involves: 129S1/Sv * 129X1/SvJ MGI:3717108
cn3
 		Myl1tm1(cre)Sjb/Myl1+
Shc1tm7Paw/Shc1tm9Paw 		involves: 129S1/Sv * 129X1/SvJ MGI:3717106
cx4
 		Shc1tm7Paw/Shc1+
Tg(MMTV-PyVT)634Mul/0 		involves: 129S1/Sv * 129X1/SvJ * FVB/N MGI:4361926


Genotype
MGI:3717094
hm1
Allelic
Composition		 Shc1tm7Paw/Shc1tm7Paw
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shc1tm7Paw mutation (0 available); any Shc1 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

behavior/neurological

muscle

nervous system




Genotype
MGI:3717108
ht2
Allelic
Composition		 Shc1tm3Paw/Shc1tm7Paw
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shc1tm3Paw mutation (0 available); any Shc1 mutation (66 available)
Shc1tm7Paw mutation (0 available); any Shc1 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal locomotor coordination ( J:122927 )
• mice display motor defects more severe than than transheterozygous Shc1tm3Paw/tm4Paw mice

nervous system
decreased muscle spindle number ( J:122927 )
• between P22 and P35, muscle spindles are abnormal and numbers are 13% of controls
• intrafusal fiber numbers are 35.9% of control numbers

muscle
decreased muscle spindle number ( J:122927 )
• between P22 and P35, muscle spindles are abnormal and numbers are 13% of controls
• intrafusal fiber numbers are 35.9% of control numbers




Genotype
MGI:3717106
cn3
Allelic
Composition		 Myl1tm1(cre)Sjb/Myl1+
Shc1tm7Paw/Shc1tm9Paw
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myl1tm1(cre)Sjb mutation (2 available); any Myl1 mutation (17 available)
Shc1tm7Paw mutation (0 available); any Shc1 mutation (66 available)
Shc1tm9Paw mutation (0 available); any Shc1 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal locomotor coordination ( J:122927 )
• motor abnormalities are similar to those observed in Shc1tm7Paw homozygotes

muscle
decreased muscle spindle number ( J:122927 )
• between P22 and P35, muscle spindle and intrafusal fiber numbers are reduced compared to controls

nervous system
decreased muscle spindle number ( J:122927 )
• between P22 and P35, muscle spindle and intrafusal fiber numbers are reduced compared to controls




Genotype
MGI:4361926
cx4
Allelic
Composition		 Shc1tm7Paw/Shc1+
Tg(MMTV-PyVT)634Mul/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shc1tm7Paw mutation (0 available); any Shc1 mutation (66 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:133325 )
• glands contain combination of tumor and hyperplastic structures
• combination of adenomas and cystic hyperplasias are seen in mammary glands
• tumor angiogenesis is decreased relative to tumors from Tg(MMTV-PyVT)634Mul single mutants
decreased metastatic potential ( J:133325 )
• number of mice displaying lung metastases is decreased compared to Tg(MMTV-PyVT)634Mul single mutants (60 vs 91 mice)
increased tumor latency ( J:133325 )
• mammary tumor latency is strongly increased compared to Tg(MMTV-PyVT)634Mul single mutants (95 days vs 66 days)

endocrine/exocrine glands
abnormal mammary gland morphology ( J:133325 )
• glands contain combination of tumor and hyperplastic structures
increased mammary gland tumor incidence ( J:133325 )
• glands contain combination of tumor and hyperplastic structures
• combination of adenomas and cystic hyperplasias are seen in mammary glands
• tumor angiogenesis is decreased relative to tumors from Tg(MMTV-PyVT)634Mul single mutants

integument
abnormal mammary gland morphology ( J:133325 )
• glands contain combination of tumor and hyperplastic structures
increased mammary gland tumor incidence ( J:133325 )
• glands contain combination of tumor and hyperplastic structures
• combination of adenomas and cystic hyperplasias are seen in mammary glands
• tumor angiogenesis is decreased relative to tumors from Tg(MMTV-PyVT)634Mul single mutants




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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory