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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Shc1tm8Paw
targeted mutation 8, Tony Pawson
MGI:3716782
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Shc1tm8Paw/Shc1tm9.1Paw involves: 129S1/Sv * 129X1/SvJ MGI:3717095
cn2
Shc1tm8Paw/Shc1tm9.1Paw
Tg(Myh6-cre)2182Mds/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N MGI:3717096


Genotype
MGI:3717095
ht1
Allelic
Composition
Shc1tm8Paw/Shc1tm9.1Paw
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shc1tm8Paw mutation (0 available); any Shc1 mutation (66 available)
Shc1tm9.1Paw mutation (0 available); any Shc1 mutation (66 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• between E12.5 and 13.5, all mutant embryos are dead




Genotype
MGI:3717096
cn2
Allelic
Composition
Shc1tm8Paw/Shc1tm9.1Paw
Tg(Myh6-cre)2182Mds/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shc1tm8Paw mutation (0 available); any Shc1 mutation (66 available)
Shc1tm9.1Paw mutation (0 available); any Shc1 mutation (66 available)
Tg(Myh6-cre)2182Mds mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• between E12.5 and 13.5, 8/19 mutant embryos are dead, compared to all mutant embryos not expressing the cre-recombined allele; remaining embryos have regularly beating hearts and normal-appearing trabeculae





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory