All Phenotypes Shc1<tm8Paw> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Shc1^tm8Paw
targeted mutation 8, Tony Pawson
MGI:3716782

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Shc1^tm8Paw/Shc1^tm9.1Paw	involves: 129S1/Sv * 129X1/SvJ	MGI:3717095
cn2	Shc1^tm8Paw/Shc1^tm9.1Paw Tg(Myh6-cre)2182Mds/0	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:3717096

Allelic Composition	Shc1^tm8Paw/Shc1^tm9.1Paw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shc1^tm8Paw mutation (0 available); any Shc1 mutation (66 available)
Shc1^tm9.1Paw mutation (0 available); any Shc1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:122927 )

• between E12.5 and 13.5, all mutant embryos are dead

Allelic Composition	Shc1^tm8Paw/Shc1^tm9.1Paw Tg(Myh6-cre)2182Mds/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:122927 )

• between E12.5 and 13.5, 8/19 mutant embryos are dead, compared to all mutant embryos not expressing the cre-recombined allele; remaining embryos have regularly beating hearts and normal-appearing trabeculae

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