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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Syt2m1Ingm
mutation 1, Ingenium Pharmaceuticals
MGI:3716868
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Syt2m1Ingm/Syt2m1Ingm Not Specified MGI:3717158


Genotype
MGI:3717158
hm1
Allelic
Composition
Syt2m1Ingm/Syt2m1Ingm
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syt2m1Ingm mutation (0 available); any Syt2 mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system

nervous system
• mice exhibit significantly longer latency, slower rise time and decreased excitatory postsynaptic currents
• when integrated over 100ms action potential induced excitatory postsynaptic currents are reduced
• at rest mice miniature excitatory postsynaptic current (mEPSC) frequency is potentiated almost five-fold that of wild-type mice
• following an action potential mini frequency is 2-fold higher than in wild-type mice
• frequency of mEPSC is increased
• miniature endplate potential in the absence or presence of extracellular calcium is several fold higher than in wild-type mice

behavior/neurological
• mice are severely uncoordinated

growth/size/body





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory