Phenotypes associated with this allele

• Allele Symbol: Syt2^m1Ingm
• Allele Name: mutation 1, Ingenium Pharmaceuticals
• Allele ID: MGI:3716868
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Syt2^m1Ingm/Syt2^m1Ingm	Not Specified	MGI:3717158

Genotype
MGI:3717158

hm1

• Allelic Composition: Syt2^m1Ingm/Syt2^m1Ingm
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

infertility ( J:108786 )

nervous system

abnormal excitatory postsynaptic currents ( J:108786 )

• mice exhibit significantly longer latency, slower rise time and decreased excitatory postsynaptic currents

• when integrated over 100ms action potential induced excitatory postsynaptic currents are reduced

prolonged excitatory postsynaptic current rise time ( J:108786 )

abnormal miniature excitatory postsynaptic currents ( J:108786 )

• at rest mice miniature excitatory postsynaptic current (mEPSC) frequency is potentiated almost five-fold that of wild-type mice

• following an action potential mini frequency is 2-fold higher than in wild-type mice

• frequency of mEPSC is increased

abnormal miniature endplate potential ( J:108786 )

• miniature endplate potential in the absence or presence of extracellular calcium is several fold higher than in wild-type mice

behavior/neurological

ataxia ( J:108786 )

impaired coordination ( J:108786 )

• mice are severely uncoordinated

growth/size/body

decreased body weight ( J:108786 )