Phenotypes associated with this allele

• Allele Symbol: Spem1^tm1Wyan
• Allele Name: targeted mutation 1, Wei Yan
• Allele ID: MGI:3716924
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Spem1^tm1Wyan/Spem1^tm1Wyan	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3717159

Genotype
MGI:3717159

hm1

• Allelic Composition: Spem1^tm1Wyan/Spem1^tm1Wyan
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Morphological and histological analyses of Spem1^tm1Wyan/Spem1^tm1Wyan mouse testes and sperm

reproductive system

asthenozoospermia ( J:120937 )

♂ • 85% of sperm are immotile with the remainder showing weak motility

abnormal spermatogenesis ( J:120937 )

♂

teratozoospermia ( J:120937 )

♂ • sperm lack cytoplasmic droplets

abnormal sperm head morphology ( J:120937 )

♂ • sperm display three types of head bends: either the heads are bent 180 degrees with the tip of the head pointing towards the tip of the tail, the head is bent gradually backwards and the neck has a groove in the middle, or the neck and middle piece of the tail wrap several times around the head

♂ • in all cases the head and neck are connected by membranous tissue

abnormal spermiogenesis ( J:120937 )

♂ • detaching and shedding of the cytoplasm is impaired and cytoplasmic droplets fail to form

male infertility ( J:120937 )

♂ • males are completely infertile

♂ • however, females are fertile

impaired fertilization ( J:120937 )

• sperm with the neck wrapped around the head fail to bind the zona pellucida

• sperm with the head bent completely backward can bind the zona pellucida but fail to penetrate

• however, injection of sperm heads into eggs results in successful fertilization

cellular

teratozoospermia ( J:120937 )

♂ • sperm lack cytoplasmic droplets

abnormal sperm head morphology ( J:120937 )

♂ • sperm display three types of head bends: either the heads are bent 180 degrees with the tip of the head pointing towards the tip of the tail, the head is bent gradually backwards and the neck has a groove in the middle, or the neck and middle piece of the tail wrap several times around the head

♂ • in all cases the head and neck are connected by membranous tissue

asthenozoospermia ( J:120937 )

♂ • 85% of sperm are immotile with the remainder showing weak motility