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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Sash3tm1Hlz
targeted mutation 1, Bernhard Holzmann
MGI:3716944
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Sash3tm1Hlz/Sash3tm1Hlz B6.129P2-Sash3tm1Hlz MGI:3717151


Genotype
MGI:3717151
hm1
Allelic
Composition
Sash3tm1Hlz/Sash3tm1Hlz
Genetic
Background
B6.129P2-Sash3tm1Hlz
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sash3tm1Hlz mutation (0 available); any Sash3 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• following treatment with a CD3 or CD28 antibody, T cell proliferation is attenuated
in vitro, CD4+ cell proliferation is severely attenuated while CD8+ proliferation is only moderately affected
• fewer CD4+ single positive cells are present compared to in wild-type mice
• more CD8+ single positive cells are present compared to in wild-type mice
• IgG1 levels are decreased
• following TNP-CGG treatment, IgG1 levels are lower than in control mice
• following TNP-CGG treatment, IgG2a levels are lower than in control mice
• IgM levels are lower than in wild-type mice
• following TNP-Ficoll treatment, IgM levels are reduced by greater than 80% compared wild-type mice
• B cell proliferation in response to IgM and CD40 is reduced
• absolute numbers are decreased by 63% compared to wild-type
• lymphoid organs including thymus, spleen, peripheral lymph nodes and Peyer's patches are reduced in total cell numbers by about 30 to 60%
• humoral response to TNP-Ficoll and TNP-CGG is attenuated
• in vitro, gamma-interferon production by CD3 antibody stimulated mutant T cells was impaired
• in vitro, IL-10 production by CD3 antibody stimulated mutant T cells was impaired
• in vitro, IL-2 production by CD3 antibody stimulated mutant T cells was impaired
• in vitro, IL-4 production by CD3 antibody stimulated mutant T cells was impaired
• in vitro, TNF production by CD3 antibody stimulated mutant T cells was impaired
• semi-identical allografts have increased survival, with half survive more than 60 days, compared to in wild-type

hematopoietic system
• following treatment with a CD3 or CD28 antibody, T cell proliferation is attenuated
in vitro, CD4+ cell proliferation is severely attenuated while CD8+ proliferation is only moderately affected
• absolute numbers are decreased by 63% compared to wild-type
• fewer CD4+ single positive cells are present compared to in wild-type mice
• more CD8+ single positive cells are present compared to in wild-type mice
• IgG1 levels are decreased
• following TNP-CGG treatment, IgG1 levels are lower than in control mice
• following TNP-CGG treatment, IgG2a levels are lower than in control mice
• IgM levels are lower than in wild-type mice
• following TNP-Ficoll treatment, IgM levels are reduced by greater than 80% compared wild-type mice
• B cell proliferation in response to IgM and CD40 is reduced

cellular
• following treatment with a CD3 or CD28 antibody, T cell proliferation is attenuated
in vitro, CD4+ cell proliferation is severely attenuated while CD8+ proliferation is only moderately affected





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory