All Phenotypes Shc1<tm9.1Paw> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Shc1^tm9.1Paw
targeted mutation 9.1, Tony Pawson
MGI:3717010

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Shc1^tm8Paw/Shc1^tm9.1Paw	involves: 129S1/Sv * 129X1/SvJ	MGI:3717095
cn2	Isl1^tm1(cre)Tmj/Isl1⁺ Shc1^tm9Paw/Shc1^tm9.1Paw	involves: 129S1/Sv * 129X1/SvJ	MGI:3717101
cn3	Shc1^tm8Paw/Shc1^tm9.1Paw Tg(Myh6-cre)2182Mds/0	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:3717096

Allelic Composition	Shc1^tm8Paw/Shc1^tm9.1Paw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shc1^tm8Paw mutation (0 available); any Shc1 mutation (66 available)
Shc1^tm9.1Paw mutation (0 available); any Shc1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:122927 )

• between E12.5 and 13.5, all mutant embryos are dead

Allelic Composition	Isl1^tm1(cre)Tmj/Isl1⁺ Shc1^tm9Paw/Shc1^tm9.1Paw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Isl1^tm1(cre)Tmj mutation (0 available); any Isl1 mutation (36 available)
Shc1^tm9.1Paw mutation (0 available); any Shc1 mutation (66 available)
Shc1^tm9Paw mutation (0 available); any Shc1 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:122927 )

• mutants appear normal

Allelic Composition	Shc1^tm8Paw/Shc1^tm9.1Paw Tg(Myh6-cre)2182Mds/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:122927 )

• between E12.5 and 13.5, 8/19 mutant embryos are dead, compared to all mutant embryos not expressing the cre-recombined allele; remaining embryos have regularly beating hearts and normal-appearing trabeculae

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24