Phenotypes associated with this allele

• Allele Symbol: tnyw
• Allele Name: tiny wasting
• Allele ID: MGI:3717082
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Pemt^tm1J/Pemt^tm1J tnyw/tnyw	B6;129P2 Pemt^tm1J-tnyw/GrsrJ	MGI:3723603

Genotype
MGI:3723603

cx1

• Allelic Composition: Pemt^tm1J/Pemt^tm1J; tnyw/tnyw
• Genetic Background: B6;129P2 Pemt^tm1J-tnyw/GrsrJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Small size of Pemt^tm1J/Pemt^tm1J tnyw/tnyw mice (left) with littermate control (right) at 2 weeks of age

mortality/aging

premature death ( J:125079 )

postnatal lethality, incomplete penetrance ( J:125079 )

• most tiny wasting homozygotes die by 3 weeks of age

nervous system

brain vacuoles ( J:125079 )

• tiny wasting homozygotes assessed at 16 days of age to 3.5 weeks of age display vacuoles in the brain

growth/size/body

decreased body size ( J:125079 )

• all tiny wasting homozygotes are smaller than heterozygous controls and can be identified by 2 weeks of age by their smaller wasting bodies

behavior/neurological

impaired righting response ( J:125079 )

• some tiny wasting homozygotes are unable to right themselves

abnormal locomotor coordination ( J:125079 )

• some tiny wasting homozygotes display abnormal locomotion

impaired limb coordination ( J:125079 )

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:125079 )

N • ABR assessment on 2 tiny wasting homozygotes failed to detect any abnormality

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:125079 )

N • histology of pituitary glands, thyroid glands, and somatic organs reveals no abnormalities