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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sox17tm1Sjm
targeted mutation 1, Sean J Morrison
MGI:3717118
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Sox17tm1Sjm/Sox17tm1Sjm BKa.129-Sox17tm1Sjm MGI:3717918
hm2
 		Sox17tm1Sjm/Sox17tm1Sjm involves: 129S1/Sv * 129X1/SvJ MGI:4356151
cn3
 		Sox17tm1Jaw/Sox17tm1Sjm
Tg(Foxa3-cre)1Khk/0 		involves: 129 * C57BL/6 * DBA MGI:4356148
cn4
 		Sox17tm1Jaw/Sox17tm1Sjm
Tg(Pdx1-cre)6Tuv/0 		involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * FVB/N MGI:4356150
cn5
 		Sox17tm1Sjm/Sox17tm2Sjm
Tg(Tek-cre)12Flv/0 		involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * C57BL/Ka MGI:3717920
cn6
 		Sox17tm1Sjm/Sox17tm2Sjm
Tg(Mx1-cre)1Cgn/0 		involves: 129/Sv * C3H * C57BL/6 * C57BL/Ka * CBA MGI:3717921


Genotype
MGI:3717918
hm1
Allelic
Composition		 Sox17tm1Sjm/Sox17tm1Sjm
Genetic
Background		 BKa.129-Sox17tm1Sjm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox17tm1Sjm mutation (1 available); any Sox17 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:123050 )
• expected numbers of homozygotes are found at E12.5, but complete lethality is observed by E13.5

embryo
abnormal embryo turning ( J:123050 )
• body axis rotation defects are observed by E11.5
abnormal rostral-caudal axis patterning ( J:123050 )
• at E11.5, embryos show severe defects in posterior patterning
embryonic growth retardation ( J:123050 )
• mice exhibit severe growth retardation by E11.5 compared to controls
abnormal embryonic hematopoiesis ( J:123050 )
• hematopoietic and erythroid cells are significantly reduced in the yolk sac and embryo at E11.5

hematopoietic system
abnormal embryonic hematopoiesis ( J:123050 )
• hematopoietic and erythroid cells are significantly reduced in the yolk sac and embryo at E11.5

liver/biliary system
liver hypoplasia ( J:123050 )
• at E12.5, livers of homozygotes are extremely hypocellular

growth/size/body
embryonic growth retardation ( J:123050 )
• mice exhibit severe growth retardation by E11.5 compared to controls




Genotype
MGI:4356151
hm2
Allelic
Composition		 Sox17tm1Sjm/Sox17tm1Sjm
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox17tm1Sjm mutation (1 available); any Sox17 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal bile duct development ( J:151981 )
• mice lack a distinguishable Ipfl (Pdx1)+ ventral bud and cells are scattered throughout the liver unlike in control mice
absent pancreas ( J:151981 )
• at E9.0, mice lack a ventral pancreas

liver/biliary system
abnormal bile duct development ( J:151981 )
• mice lack a distinguishable Ipfl (Pdx1)+ ventral bud and cells are scattered throughout the liver unlike in control mice




Genotype
MGI:4356148
cn3
Allelic
Composition		 Sox17tm1Jaw/Sox17tm1Sjm
Tg(Foxa3-cre)1Khk/0
Genetic
Background		 involves: 129 * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox17tm1Jaw mutation (1 available); any Sox17 mutation (29 available)
Sox17tm1Sjm mutation (1 available); any Sox17 mutation (29 available)
Tg(Foxa3-cre)1Khk mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal bile duct development ( J:151981 )
• at E9.5, Ipfl (Pdx1)+ cells are found throughout the liver bud unlike in control mice
• at E10.5, the biliary/gall bladder primordium is absent unlike in control mice
• however, cell proliferation and apoptosis rates are normal

liver/biliary system
abnormal bile duct development ( J:151981 )
• at E9.5, Ipfl (Pdx1)+ cells are found throughout the liver bud unlike in control mice
• at E10.5, the biliary/gall bladder primordium is absent unlike in control mice
• however, cell proliferation and apoptosis rates are normal




Genotype
MGI:4356150
cn4
Allelic
Composition		 Sox17tm1Jaw/Sox17tm1Sjm
Tg(Pdx1-cre)6Tuv/0
Genetic
Background		 involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox17tm1Jaw mutation (1 available); any Sox17 mutation (29 available)
Sox17tm1Sjm mutation (1 available); any Sox17 mutation (29 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal bile duct development ( J:151981 )
• at E9.5, Ipfl (Pdx1)+ cells are found throughout the liver bud unlike in control mice
• at E10.0, the biliary primordium is absent unlike in control mice
absent gallbladder ( J:151981 )
• at E16.5

liver/biliary system
abnormal bile duct development ( J:151981 )
• at E9.5, Ipfl (Pdx1)+ cells are found throughout the liver bud unlike in control mice
• at E10.0, the biliary primordium is absent unlike in control mice
absent gallbladder ( J:151981 )
• at E16.5




Genotype
MGI:3717920
cn5
Allelic
Composition		 Sox17tm1Sjm/Sox17tm2Sjm
Tg(Tek-cre)12Flv/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 * C57BL/Ka
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox17tm1Sjm mutation (1 available); any Sox17 mutation (29 available)
Sox17tm2Sjm mutation (1 available); any Sox17 mutation (29 available)
Tg(Tek-cre)12Flv mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:123050 )
• expected numbers of homozygotes are found at E12.5, but complete lethality is observed by E13.5

embryo
embryonic growth retardation ( J:123050 )
• at E12.5, mutants are growth retarded
abnormal embryonic hematopoiesis ( J:123050 )
• no hematopoiesis is visible in the yolk sac or embryo at E12.5

growth/size/body
embryonic growth retardation ( J:123050 )
• at E12.5, mutants are growth retarded

hematopoietic system
abnormal embryonic hematopoiesis ( J:123050 )
• no hematopoiesis is visible in the yolk sac or embryo at E12.5




Genotype
MGI:3717921
cn6
Allelic
Composition		 Sox17tm1Sjm/Sox17tm2Sjm
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129/Sv * C3H * C57BL/6 * C57BL/Ka * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox17tm1Sjm mutation (1 available); any Sox17 mutation (29 available)
Sox17tm2Sjm mutation (1 available); any Sox17 mutation (29 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:123050 )
• death of all mice by 14 days after birth

hematopoietic system
thymus hypoplasia ( J:123050 )
• mice display severe reduction in thymus cellularity upon examination at 4-5 days after end of poly(I:C) treatment
decreased bone marrow cell number ( J:123050 )
• when sacrificed 4-5 days after end of poly(I:C) treatment, reduced bone marrow cellularity is observed
thrombocytopenia ( J:123050 )
• numbers are significantly reduce compared to controls following cre induction
decreased leukocyte cell number ( J:123050 )
• numbers are significantly reduce compared to controls following cre induction
decreased hematopoietic stem cell number ( J:123050 )
• HSCs are reduced in bone marrow and spleen
spleen hypoplasia ( J:123050 )
• when sacrificed 4-5 days after end of poly(I:C) treatment, reduced spleen cellularity is observed

immune system
thymus hypoplasia ( J:123050 )
• mice display severe reduction in thymus cellularity upon examination at 4-5 days after end of poly(I:C) treatment
decreased leukocyte cell number ( J:123050 )
• numbers are significantly reduce compared to controls following cre induction
spleen hypoplasia ( J:123050 )
• when sacrificed 4-5 days after end of poly(I:C) treatment, reduced spleen cellularity is observed

endocrine/exocrine glands
thymus hypoplasia ( J:123050 )
• mice display severe reduction in thymus cellularity upon examination at 4-5 days after end of poly(I:C) treatment




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory