All Phenotypes St14<Gt(XM184)Byg> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	St14^Gt(XM184)Byg/St14^Gt(XM184)Byg	involves: 129P2/OlaHsd * Black Swiss	MGI:3717474
ht2	St14^Gt(XM184)Byg/St14⁺	involves: 129P2/OlaHsd * Black Swiss	MGI:3717475
cx3	Spint1^tm1Bug/Spint1^tm1Bug St14^Gt(XM184)Byg/St14^Gt(XM184)Byg	involves: 129P2/OlaHsd * 129S6/SvEvTac * NIH Black Swiss	MGI:3822303

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:142708 )

• born at near normal numbers

• die within the first day after birth

digestive/alimentary system

abnormal hard palate morphology ( J:108567 )

• the keratinized epithelium of the tongue and hard palate has increased permeability as measured by a dye absorption assay

abnormal tongue epithelium morphology ( J:108567 )

• the keratinized epithelium of the tongue and hard palate has increased permeability as measured by a dye absorption assay

craniofacial

abnormal hard palate morphology ( J:108567 )

• the keratinized epithelium of the tongue and hard palate has increased permeability as measured by a dye absorption assay

abnormal tongue epithelium morphology ( J:108567 )

• the keratinized epithelium of the tongue and hard palate has increased permeability as measured by a dye absorption assay

behavior/neurological

absent gastric milk in neonates ( J:142708 )

• 75% of homozygous mutant pups lack milk spots in the stomach

integument

abnormal epidermis stratum corneum morphology ( J:142708 )

abnormal corneocyte morphology ( J:142708 )

• tightly packed immature corneocytes

growth/size/body

abnormal hard palate morphology ( J:108567 )

• the keratinized epithelium of the tongue and hard palate has increased permeability as measured by a dye absorption assay

abnormal tongue epithelium morphology ( J:108567 )

• the keratinized epithelium of the tongue and hard palate has increased permeability as measured by a dye absorption assay

Allelic Composition	St14^Gt(XM184)Byg/St14⁺
Genetic Background	involves: 129P2/OlaHsd * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
St14^Gt(XM184)Byg mutation (0 available); any St14 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

impaired skin barrier function ( J:108567 )

• at E14.5 and E15.5, mice have reduced epithelial barrier function as measured by a dye assay

integument

impaired skin barrier function ( J:108567 )

• at E14.5 and E15.5, mice have reduced epithelial barrier function as measured by a dye assay

Allelic Composition	Spint1^tm1Bug/Spint1^tm1Bug St14^Gt(XM184)Byg/St14^Gt(XM184)Byg
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * NIH Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spint1^tm1Bug mutation (0 available); any Spint1 mutation (26 available)
St14^Gt(XM184)Byg mutation (0 available); any St14 mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:142708 )

• double homozygotes born at near normal numbers

• die within the first day after birth

embryo

embryo phenotype ( J:142708 )

N	• placentas normal, including labyrinth layer • no growth retardation

behavior/neurological

absent gastric milk in neonates ( J:142708 )

• 75% of double homozygous mutant pups lack milk spots in the stomach

integument

absent vibrissae ( J:142708 )

• absence of erupted whiskers

abnormal epidermal layer morphology ( J:142708 )

• reddish, wrinkled, dry

abnormal epidermis stratum corneum morphology ( J:142708 )

abnormal corneocyte morphology ( J:142708 )

• tightly packed immature corneocytes

thin epidermis ( J:142708 )

dry skin ( J:142708 )

reddish skin ( J:142708 )

wrinkled skin ( J:142708 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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