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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(ACTB-tTS)1Mllo
transgene insertion 1, Moises Mallo
MGI:3717162
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Rr96tm1.1Tich/Rr96tm1.1Tich
Tg(ACTB-tTS)1Mllo/? 		involves: 129 * C57BL/6 MGI:5470228


Genotype
MGI:5470228
cx1
Allelic
Composition		 Rr96tm1.1Tich/Rr96tm1.1Tich
Tg(ACTB-tTS)1Mllo/?
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rr96tm1.1Tich mutation (0 available); any Rr96 mutation (0 available)
Tg(ACTB-tTS)1Mllo mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased double-positive T cell number ( J:191711 )
• double positive T cells are converted to CD4- CD8+ TCR-/lo cells
• a population of TCR+ CD4- CD8-/lo cells is found in both the thymus and the periphery
• doxycycine treatmen reverses T cell changes in the thymus but not in peripheral T cells

hematopoietic system
decreased double-positive T cell number ( J:191711 )
• double positive T cells are converted to CD4- CD8+ TCR-/lo cells
• a population of TCR+ CD4- CD8-/lo cells is found in both the thymus and the periphery
• doxycycine treatmen reverses T cell changes in the thymus but not in peripheral T cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory