Phenotypes associated with this allele

• Allele Symbol: Tg(Eno2-APOE_i4)1Rabr
• Allele Name: transgene insertion 1, Jacob Raber
• Allele ID: MGI:3717178
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Apoe^tm1Unc/Apoe^tm1Unc Tg(Eno2-APOE_i4)1Rabr/0	involves: 129P2/OlaHsd * C57BL/6J * ICR	MGI:3717195
cx2	Apoe^tm1Unc/Apoe^tm1Unc Tg(Eno2-APOE_i4)1Rabr/0	involves: 129P2/OlaHsd * ICR	MGI:3718008

Genotype
MGI:3717195

cx1

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Tg(Eno2-APOE_i4)1Rabr/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:100975 )

N • coordination levels measured in rotorod tests are similar to wild-type, as is passive avoidance learning

N • 6-month old females show similar performance in spatial learning (Morris water maze)

abnormal spatial learning ( J:100975 )

• 6-month old males show significantly higher latency to locate platform compared to females

decreased vertical activity ( J:100975 )

nervous system

nervous system phenotype ( J:55835 )

N • upon 18 mg/kg kainic acid injection, significant loss of neocortical synaptophysin-positive presynaptic terminals and disruption of hippocampal axons are observed, similar to wild-type

neurodegeneration ( J:55835 , J:100975 )

• mice show significant loss of synaptophysin-positive presynaptic terminals and neuronal dendrites of the neocortex and hippocampus with age (7-9 months compared to 3-4 months) (J:55835)

• mice display similar degeneration to that observed in Apoe-deficient mice (J:100975)

Genotype
MGI:3718008

cx2

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Tg(Eno2-APOE_i4)1Rabr/0
• Genetic Background: involves: 129P2/OlaHsd * ICR

behavior/neurological

increased anxiety-related response ( J:101973 )

• in the elevated-plus maze, mice show increased anxiety with reduced time and distance moved in the open arms; mice have significantly lower number of open-arm entries than wild-type

increased startle reflex ( J:101973 )

• response is higher in mice at 6 months of age compared to wild-type or Tg(Eno2-APOE*3)1Rabr/Apoe^tm1Unc mice but lower than Apoe^tm1Unc single mutants

nervous system

abnormal dendrite morphology ( J:101973 )

• mutants have lower levels of MAP 2-positive neuronal dendrites than wild-type; at 3 months, levels are similar in mutants and controls