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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tlr2lngd
languid
MGI:3717224
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tlr2lngd/Tlr2lngd C57BL/6J-Tlr2lngd MGI:3717226


Genotype
MGI:3717226
hm1
Allelic
Composition		 Tlr2lngd/Tlr2lngd
Genetic
Background		 C57BL/6J-Tlr2lngd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tlr2lngd mutation (1 available); any Tlr2 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:94077 )
• mutant macrophages do not respond to diacyl or triacyl lipopeptides or other TLR2-dependent microbial signature molecules
increased susceptibility to bacterial infection ( J:94077 )
• mice are immunocompromised in response to Gram-positive bacterial infection

hematopoietic system
abnormal macrophage physiology ( J:94077 )
• mutant macrophages do not respond to diacyl or triacyl lipopeptides or other TLR2-dependent microbial signature molecules




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory