Phenotypes associated with this allele

• Allele Symbol: Tg(Ckm-PTPN1)45Bbk
• Allele Name: transgene insertion 45, Barbara B Kahn
• Allele ID: MGI:3717234
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(Ckm-PTPN1)45Bbk/? Tg(Ckm-PTPRF)13Bbk/?	involves: FVB	MGI:4819967
tg2	Tg(Ckm-PTPN1)45Bbk/0	involves: FVB	MGI:4819964

Genotype
MGI:4819967

cx1

• Allelic Composition: Tg(Ckm-PTPN1)45Bbk/?; Tg(Ckm-PTPRF)13Bbk/?
• Genetic Background: involves: FVB

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:122895 )

N • blood glucose and serum insulin levels are similar to control

abnormal glucose homeostasis ( J:122895 )

abnormal glycogen homeostasis ( J:122895 )

• muscle glycogen synthesis is slightly decreased

insulin resistance ( J:122895 )

• glucose infusion rate needed to maintain euglycemia is decreased by 36% as compared to control

growth/size/body

growth/size/body region phenotype ( J:122895 )

N • body weight and perigonadal fat pad weight is similar to control

muscle

decreased skeletal muscle cell glucose uptake ( J:122895 )

• insulin-stimulated glucose transport into skeletal muscle is impaired by 40-50% as compared to control

• glycolysis in skeletal muscle is impaired

cellular

decreased skeletal muscle cell glucose uptake ( J:122895 )

• insulin-stimulated glucose transport into skeletal muscle is impaired by 40-50% as compared to control

• glycolysis in skeletal muscle is impaired

Genotype
MGI:4819964

tg2

• Allelic Composition: Tg(Ckm-PTPN1)45Bbk/0
• Genetic Background: involves: FVB

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:122895 )

N • blood glucose and serum insulin levels are similar to control

abnormal glucose homeostasis ( J:122895 )

abnormal glycogen homeostasis ( J:122895 )

• muscle glycogen synthesis is slightly decreased

insulin resistance ( J:122895 )

• glucose infusion rate needed to maintain euglycemia is decreased by 37% as compared to control

growth/size/body

growth/size/body region phenotype ( J:122895 )

N • body weight and perigonadal fat pad weight is similar to control

muscle

decreased skeletal muscle cell glucose uptake ( J:122895 )

• insulin-stimulated glucose transport into skeletal muscle is impaired by 40-50% as compared to control

• glycolysis in skeletal muscle is impaired

cellular

decreased skeletal muscle cell glucose uptake ( J:122895 )

• insulin-stimulated glucose transport into skeletal muscle is impaired by 40-50% as compared to control

• glycolysis in skeletal muscle is impaired