Phenotypes associated with this allele

• Allele Symbol: Tg(Ckm-DGAT2)10Far
• Allele Name: transgene insertion 10, Bob Farese
• Allele ID: MGI:3717406
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Ckm-DGAT2)10Far/0	involves: C57BL/6NHsd	MGI:3769441

Genotype
MGI:3769441

tg1

• Allelic Composition: Tg(Ckm-DGAT2)10Far/0
• Genetic Background: involves: C57BL/6NHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal glucose homeostasis ( J:129495 )

• basal uptake of 2-deoxyglucose in glycolytic and oxidative muscle trend higher in transgenic mice compared to wild-type

impaired glucose tolerance ( J:129495 )

• tolerance is impaired at 15, 30, and 60 minutes after glucose challenge in 3-month old males

insulin resistance ( J:129495 )

• in response to insulin, 2-deoxyglucose uptake is impaired in glycolytic muscle, while uptake is stimulated ~2-fold in wild-type glycolytic muscle by insulin

• 3-month old male mice show impaired insulin tolerance with higher glucose levels 60 minutes after insulin injection compared to wild-type

abnormal lipid level ( J:129495 )

• at 3 months in males, diglyceride levels are 42% lower in glycolytic muscle compared to wild-type; ceramide levels are 63% higher and some saturated acyl CoA species are elevated also whereas levels in oxidative muscle are similar in transgenic and wild-type mice

• by 6 months of age, lipid content in glycolytic muscle increase to similar levels in both genotypes

increased skeletal muscle triglyceride level ( J:129495 )

• in 3 month-old male mice, transgene expression increases triglyceride level in glycolytic muscle 1.8-fold, while levels in oxidative muscle, white adipose tissue and liver are similar to wild-type levels

• by 6 months of age, triglyceride content in glycolytic muscle increase to similar levels in both genotypes

muscle

increased skeletal muscle triglyceride level ( J:129495 )

• in 3 month-old male mice, transgene expression increases triglyceride level in glycolytic muscle 1.8-fold, while levels in oxidative muscle, white adipose tissue and liver are similar to wild-type levels

• by 6 months of age, triglyceride content in glycolytic muscle increase to similar levels in both genotypes