All Phenotypes Tg(Pbsn-cre)20Fwan MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Pbsn-cre)20Fwan
transgene insertion 20, Fen Wang
MGI:3717407

Summary

10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pten^tm1Hwu/Pten^tm1Hwu Tg(Pbsn-cre)20Fwan/?	involves: 129S4/SvJae * C57BL/6 * FVB/NCrl	MGI:5827768
cn2	Gt(ROSA)26Sor^tm1(JAG1)Xin/Gt(ROSA)26Sor⁺ Pten^tm1Hwu/Pten^tm1Hwu Tg(Pbsn-cre)20Fwan/?	involves: 129S4/SvJae * C57BL/6 * FVB/NCrl	MGI:5827766
cn3	Kras^tm4Tyj/Kras⁺ Tg(Pbsn-cre)20Fwan/0	involves: 129S4/SvJae * FVB/NCrl	MGI:5300203
cn4	Kras^tm4Tyj/Kras⁺ Scrib^tm1.1Phum/Scrib^tm1.1Phum Tg(Pbsn-cre)20Fwan/0	involves: 129S4/SvJae * FVB/NCrl	MGI:5300204
cn5	Kras^tm4Tyj/Kras⁺ Scrib^tm1.1Phum/Scrib⁺ Tg(Pbsn-cre)20Fwan/0	involves: 129S4/SvJae * FVB/NCrl	MGI:5300205
cn6	Ar^tm1Jdz/Y Tg(Pbsn-cre)20Fwan/?	involves: 129X1/SvJ * C57BL/6 * FVB/NCrl	MGI:3717428
cn7	Ar^tm1Jdz/Y Tg(Pbsn-cre)20Fwan/?	involves: 129X1/SvJ * C57BL/6J * FVB/NCrl	MGI:4361177
cn8	Gt(ROSA)26Sor^tm1(JAG1)Xin/Gt(ROSA)26Sor⁺ Tg(Pbsn-cre)20Fwan/?	involves: C57BL/6 * FVB/NCrl	MGI:5827764
cn9	Wdr77^tm2Zwan/Wdr77^tm2Zwan Tg(Pbsn-cre)20Fwan/0	involves: C57BL/6J * FVB/NCrl	MGI:4821123
cn10	Scrib^tm1.1Phum/Scrib^tm1.1Phum Tg(Pbsn-cre)20Fwan/0	involves: FVB/NCrl	MGI:5300202

Allelic Composition	Pten^tm1Hwu/Pten^tm1Hwu Tg(Pbsn-cre)20Fwan/?
Genetic Background	involves: 129S4/SvJae * C57BL/6 * FVB/NCrl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pten^tm1Hwu mutation (16 available); any Pten mutation (88 available)
Tg(Pbsn-cre)20Fwan mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased prostate gland adenocarcinoma incidence ( J:238768 )

• mice develop high grade prostatic intraepithelial neoplasia at 32 weeks and focal adenocarcinoma by one year

increased prostate intraepithelial neoplasia incidence ( J:238768 )

• mice develop high grade prostatic intraepithelial neoplasia at 32 weeks and focal adenocarcinoma by one year

• prostate tissue in 2/8 mutant mice contains large papillary structures with complex glandular architecture

• mice develop a lower grade reactive stroma with lymphocytic infiltration as compared to mice with JAG1 overexpression

neoplasm

increased prostate gland adenocarcinoma incidence ( J:238768 )

• mice develop high grade prostatic intraepithelial neoplasia at 32 weeks and focal adenocarcinoma by one year

increased prostate intraepithelial neoplasia incidence ( J:238768 )

• mice develop high grade prostatic intraepithelial neoplasia at 32 weeks and focal adenocarcinoma by one year

• prostate tissue in 2/8 mutant mice contains large papillary structures with complex glandular architecture

• mice develop a lower grade reactive stroma with lymphocytic infiltration as compared to mice with JAG1 overexpression

reproductive system

increased prostate gland adenocarcinoma incidence ( J:238768 )

• mice develop high grade prostatic intraepithelial neoplasia at 32 weeks and focal adenocarcinoma by one year

increased prostate intraepithelial neoplasia incidence ( J:238768 )

• mice develop high grade prostatic intraepithelial neoplasia at 32 weeks and focal adenocarcinoma by one year

• prostate tissue in 2/8 mutant mice contains large papillary structures with complex glandular architecture

• mice develop a lower grade reactive stroma with lymphocytic infiltration as compared to mice with JAG1 overexpression

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:238768

Allelic Composition	Gt(ROSA)26Sor^tm1(JAG1)Xin/Gt(ROSA)26Sor⁺ Pten^tm1Hwu/Pten^tm1Hwu Tg(Pbsn-cre)20Fwan/?
Genetic Background	involves: 129S4/SvJae * C57BL/6 * FVB/NCrl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1(JAG1)Xin mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Pten^tm1Hwu mutation (16 available); any Pten mutation (88 available)
Tg(Pbsn-cre)20Fwan mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal prostate gland morphology ( J:238768 )

• increase in number CD45+ leukocytes in prostate tissue as compared to control (lacking JAG1 over expression)

• prostate tissue in 15/16 mutant mice contains large papillary structures with complex glandular architecture

• blood vessel density in prostate is 1.8 fold more than in control

• increased collagen deposition at the prostatic peri-glandular spaces

• presence of reactive stroma

• stromal cell layer is disrupted and thinner with increased vimentin staining in peri-glandular stromal cells

• prostate tissues contain more inflammatory foci as compared to controls (lacking JAG1 overexpression)

increased prostate gland adenocarcinoma incidence ( J:238768 )

• 62.5% mutant mice (as compared to 20% in controls lacking JAG1 overexpression) have a mass of poorly differentiated adenocarcinoma extended into lumen of seminal vesicles and replacing the normal lining of epithelium

• mice develop high grade prostatic intraepithelial neoplasia at 32 weeks and focal adenocarcinoma by one year

increased prostate intraepithelial neoplasia incidence ( J:238768 )

• mice develop high grade prostatic intraepithelial neoplasia at 32 weeks and focal adenocarcinoma by one year

• mice develop a higher grade reactive stroma with lymphocytic infiltration as compared to control (lacking JAG1 overexpression)

neoplasm

increased prostate gland adenocarcinoma incidence ( J:238768 )

• mice develop high grade prostatic intraepithelial neoplasia at 32 weeks and focal adenocarcinoma by one year

increased prostate intraepithelial neoplasia incidence ( J:238768 )

• mice develop high grade prostatic intraepithelial neoplasia at 32 weeks and focal adenocarcinoma by one year

• mice develop a higher grade reactive stroma with lymphocytic infiltration as compared to control (lacking JAG1 overexpression)

reproductive system

abnormal prostate gland morphology ( J:238768 )

• increase in number CD45+ leukocytes in prostate tissue as compared to control (lacking JAG1 over expression)

• prostate tissue in 15/16 mutant mice contains large papillary structures with complex glandular architecture

• blood vessel density in prostate is 1.8 fold more than in control

• increased collagen deposition at the prostatic peri-glandular spaces

• presence of reactive stroma

• stromal cell layer is disrupted and thinner with increased vimentin staining in peri-glandular stromal cells

• prostate tissues contain more inflammatory foci as compared to controls (lacking JAG1 overexpression)

increased prostate gland adenocarcinoma incidence ( J:238768 )

• mice develop high grade prostatic intraepithelial neoplasia at 32 weeks and focal adenocarcinoma by one year

increased prostate intraepithelial neoplasia incidence ( J:238768 )

• mice develop high grade prostatic intraepithelial neoplasia at 32 weeks and focal adenocarcinoma by one year

• mice develop a higher grade reactive stroma with lymphocytic infiltration as compared to control (lacking JAG1 overexpression)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:238768

Allelic Composition	Kras^tm4Tyj/Kras⁺ Tg(Pbsn-cre)20Fwan/0
Genetic Background	involves: 129S4/SvJae * FVB/NCrl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm4Tyj mutation (9 available); any Kras mutation (84 available)
Tg(Pbsn-cre)20Fwan mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

prostate gland hyperplasia ( J:178461 )

• low-grade in 73% of mice

• high-grade in 18% of mice

increased prostate intraepithelial neoplasia incidence ( J:178461 )

• in 9% of mice

abnormal prostate gland physiology ( J:178461 )

• increased cell proliferation and apoptosis compared to in Tg(Pbsn-cre)20Fwan mice

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:178461 )

• in 9% of mice

digestive/alimentary system

abnormal intestine morphology ( J:178461 )

• focal intestinal metaplasia

endocrine/exocrine glands

prostate gland hyperplasia ( J:178461 )

• low-grade in 73% of mice

• high-grade in 18% of mice

increased prostate intraepithelial neoplasia incidence ( J:178461 )

• in 9% of mice

abnormal prostate gland physiology ( J:178461 )

• increased cell proliferation and apoptosis compared to in Tg(Pbsn-cre)20Fwan mice

Allelic Composition	Kras^tm4Tyj/Kras⁺ Scrib^tm1.1Phum/Scrib^tm1.1Phum Tg(Pbsn-cre)20Fwan/0
Genetic Background	involves: 129S4/SvJae * FVB/NCrl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm4Tyj mutation (9 available); any Kras mutation (84 available)
Scrib^tm1.1Phum mutation (0 available); any Scrib mutation (54 available)
Tg(Pbsn-cre)20Fwan mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:178461 )

• 3 of 10 mice exhibit signs of illness and were sacrificed prior to 400 days

reproductive system

prostate gland hyperplasia ( J:178461 )

increased prostate gland adenocarcinoma incidence ( J:178461 )

• well-differentiated adenocarcinomas in 20% of mice

increased prostate intraepithelial neoplasia incidence ( J:178461 )

• high-grade in 33% of mice

abnormal prostate gland physiology ( J:178461 )

• increased cell proliferation and apoptosis compared to in Tg(Pbsn-cre)20Fwan mice

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:178461 )

• high-grade in 33% of mice

increased carcinoma incidence ( J:178461 )

• 3 of 15 mice develop poorly differentiated invasive carcinoma

increased prostate gland adenocarcinoma incidence ( J:178461 )

• well-differentiated adenocarcinomas in 20% of mice

digestive/alimentary system

abnormal intestine morphology ( J:178461 )

• focal intestinal metaplasia

endocrine/exocrine glands

prostate gland hyperplasia ( J:178461 )

increased prostate gland adenocarcinoma incidence ( J:178461 )

• well-differentiated adenocarcinomas in 20% of mice

increased prostate intraepithelial neoplasia incidence ( J:178461 )

• high-grade in 33% of mice

abnormal prostate gland physiology ( J:178461 )

• increased cell proliferation and apoptosis compared to in Tg(Pbsn-cre)20Fwan mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:178461

Allelic Composition	Kras^tm4Tyj/Kras⁺ Scrib^tm1.1Phum/Scrib⁺ Tg(Pbsn-cre)20Fwan/0
Genetic Background	involves: 129S4/SvJae * FVB/NCrl

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

increased prostate gland adenocarcinoma incidence ( J:178461 )

• well-differentiated adenocarcinomas in 13% of mice

increased prostate intraepithelial neoplasia incidence ( J:178461 )

• high-grade in 20% of mice

abnormal prostate gland physiology ( J:178461 )

• increased cell proliferation and apoptosis compared to in Tg(Pbsn-cre)20Fwan mice

neoplasm

increased prostate gland adenocarcinoma incidence ( J:178461 )

• well-differentiated adenocarcinomas in 13% of mice

increased prostate intraepithelial neoplasia incidence ( J:178461 )

• high-grade in 20% of mice

digestive/alimentary system

abnormal intestine morphology ( J:178461 )

• focal intestinal metaplasia

endocrine/exocrine glands

increased prostate gland adenocarcinoma incidence ( J:178461 )

• well-differentiated adenocarcinomas in 13% of mice

increased prostate intraepithelial neoplasia incidence ( J:178461 )

• high-grade in 20% of mice

abnormal prostate gland physiology ( J:178461 )

• increased cell proliferation and apoptosis compared to in Tg(Pbsn-cre)20Fwan mice

Allelic Composition	Ar^tm1Jdz/Y Tg(Pbsn-cre)20Fwan/?
Genetic Background	involves: 129X1/SvJ * C57BL/6 * FVB/NCrl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ar^tm1Jdz mutation (1 available); any Ar mutation (23 available)
Tg(Pbsn-cre)20Fwan mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal prostate gland morphology ( J:122327 )

• despite a normal macroscopic appearance with normal epithelial branching and normal numbers of ductal tips, all prostate lobes are small by weight

• stroma is reduced and eosinophilic secretion in prostatic lumen is limited

• abnormal clustering of epithelial cells in the anterior lobe and to a lesser extent in the dorsolateral and ventral prostate are present

• increased proliferation of epithelial cells in the anterior prostate

• increased density of basal epithelial cells surrounding the abnormal epithelial cell clusters in the anterior prostate

• absolute volume of each cellular compartment (stroma, lumen, and epithelium) is significantly reduced in the dorsolateral and anterior prostate lobes

abnormal prostate gland anterior lobe morphology ( J:122327 )

• increased proliferation and abnormal lesions of epithelial cells predominantly in the anterior prostate lobe at 8 weeks of age

small prostate gland anterior lobe ( J:122327 )

abnormal prostate gland epithelium morphology ( J:122327 )

• impaired structural and functional cellular differentiation of the prostate epithelium, predominantly in the anterior and dorsolateral lobes

• in anterior and dorsolateral prostate lobes, the epithelium is increased from 38 to 54% and from 32 to 48%, respectively, whereas lumen is decreased from 29 to 18% and 27 to 20%, respectively

• in ventral prostate lobes, stromal volume is unchanged, luminal volume is nonsignificantly reduced but absolute epithelial volume is markedly reduced

small prostate gland ( J:122327 )

• at 8 weeks of age, all prostate lobes are smaller than normal

decreased prostate gland weight ( J:122327 )

• at 8 weeks of age, the weights of anterior, dorsolateral and ventral lobes are decreased by 64%, 53% and 20%, respectively, relative to control values

small prostate gland ventral lobe ( J:122327 )

abnormal seminal vesicle epithelium morphology ( J:122327 )

• abnormal multilayered epithelium is present in the seminal vesicles

decreased seminal vesicle weight ( J:122327 )

• seminal vesicles weigh 45% of that in wild-type mice

decreased epididymis weight ( J:122327 )

• at 8 weeks of age, significantly reduced epididymal weights despite normal testis weights and normal serum testosterone concentrations in mature males

endocrine/exocrine glands

abnormal prostate gland morphology ( J:122327 )

• despite a normal macroscopic appearance with normal epithelial branching and normal numbers of ductal tips, all prostate lobes are small by weight

• stroma is reduced and eosinophilic secretion in prostatic lumen is limited

• abnormal clustering of epithelial cells in the anterior lobe and to a lesser extent in the dorsolateral and ventral prostate are present

• increased proliferation of epithelial cells in the anterior prostate

• increased density of basal epithelial cells surrounding the abnormal epithelial cell clusters in the anterior prostate

• absolute volume of each cellular compartment (stroma, lumen, and epithelium) is significantly reduced in the dorsolateral and anterior prostate lobes

abnormal prostate gland anterior lobe morphology ( J:122327 )

• increased proliferation and abnormal lesions of epithelial cells predominantly in the anterior prostate lobe at 8 weeks of age

small prostate gland anterior lobe ( J:122327 )

abnormal prostate gland epithelium morphology ( J:122327 )

• impaired structural and functional cellular differentiation of the prostate epithelium, predominantly in the anterior and dorsolateral lobes

• in anterior and dorsolateral prostate lobes, the epithelium is increased from 38 to 54% and from 32 to 48%, respectively, whereas lumen is decreased from 29 to 18% and 27 to 20%, respectively

• in ventral prostate lobes, stromal volume is unchanged, luminal volume is nonsignificantly reduced but absolute epithelial volume is markedly reduced

small prostate gland ( J:122327 )

• at 8 weeks of age, all prostate lobes are smaller than normal

decreased prostate gland weight ( J:122327 )

• at 8 weeks of age, the weights of anterior, dorsolateral and ventral lobes are decreased by 64%, 53% and 20%, respectively, relative to control values

small prostate gland ventral lobe ( J:122327 )

abnormal seminal vesicle epithelium morphology ( J:122327 )

• abnormal multilayered epithelium is present in the seminal vesicles

decreased seminal vesicle weight ( J:122327 )

• seminal vesicles weigh 45% of that in wild-type mice

growth/size/body

growth/size/body region phenotype ( J:122327 )

N	• at 8 weeks of age, males are overtly healthy with normal physical activity and normal body weights relative to control littermates

Allelic Composition	Ar^tm1Jdz/Y Tg(Pbsn-cre)20Fwan/?
Genetic Background	involves: 129X1/SvJ * C57BL/6J * FVB/NCrl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ar^tm1Jdz mutation (1 available); any Ar mutation (23 available)
Tg(Pbsn-cre)20Fwan mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:137429 )

N	• mutant males display normal testis morphology and sperm production

abnormal sperm flagellum morphology ( J:137429 )

• during in vitro fertilization, sperm released from mutant cauda epididymis show an increase in abnormal coiled and bent tails with hairpin structures

coiled sperm flagellum ( J:137429 )

hairpin sperm flagellum ( J:137429 )

kinked sperm flagellum ( J:137429 )

abnormal seminal vesicle morphology ( J:137429 )

• although the size of lumen is reduced it is still filled with strongly eosinophilic secretions, suggestive of partly preserved epithelial secretory function

abnormal seminal vesicle epithelium morphology ( J:137429 )

• in the proximal region, the epithelial cells of mutant seminal vesicles appear to be quite low, cuboidal, and with very little cytoplasm, while the epithelial layer is less folded than normal

• in the distal region, the epithelium exhibits a normal, tall secretory morphology, with occasional small foci of hyperplastic epithelial cells and a decrease in the size of the acini

abnormal seminal vesicle muscle layer morphology ( J:137429 )

• the stromal smooth muscle layer appears disorganized and thinner than normal

small seminal vesicle ( J:137429 )

• at 8 weeks of age, the size of mutant seminal vesicles is only 55% of that in control littemates

decreased seminal vesicle weight ( J:137429 )

• at 8 weeks of age, the weight of seminal vesicle secretion and emptied gland is significantly reduced

abnormal sperm number ( J:137429 )

• despite normal testis sperm production, sperm numbers are reduced in the caput, normal in the corpus, but significantly increased in the cauda epididymis, suggesting altered sperm epididymal transit kinetics

abnormal cauda epididymis morphology ( J:137429 )

• mutant epididymi display stromal thickening in the cauda region

abnormal corpus epididymis morphology ( J:137429 )

• mutant epididymi display stromal thickening in the corpus region

abnormal copulatory plug biosynthesis ( J:137429 )

• at 4 hrs after coitus, plugs are detected in equivalent proportions of females mating with control or mutant males; however, plugs formed by mutant males are significantly smaller, lighter, and softer with a fibrous consistency

decreased litter size ( J:137429 )

• the few mutant males that sired a litter yielded an average of 6.2 1.8 pups/litter relative to 9.6 2.7 pups/litter for control males

reduced male fertility ( J:137429 )

• unlike control males which yielded an average of 3.7 0.4 litters over a 90-day mating period, only 5 of 15 mutant males (33%) had a single litter, and only 1 of 15 had two litters within the same mating period

• median time to the first litter was 21 days and 42 days for second litter for control males, compared with >90 days for both first and second litters for mutant males

premature acrosome reaction ( J:137429 )

• mutant cauda epididymal sperm show an increased rate of spontaneous acrosome reaction relative to wild-type sperm; hyperactivated, more erratic, and whiplash-like movement typical of capacitated sperm are observed

impaired fertilization ( J:137429 )

• in vivo fertility, as measured by oocytes fertilized by mutant males mated with hyperstimulated females at 6 hrs after copulation, is significantly reduced

• in vitro fertilization capacity of mutant cauda epididymal sperm is significantly reduced at lower sperm concentrations (<50,000 sperm/ml) but not at higher sperm concentrations (>50,000 sperm/ml), indicating a mild defect in sperm binding to the zona pellucida that can be overcome by higher sperm numbers

behavior/neurological

decreased copulatory plug deposition ( J:137429 )

• after overnight mating with mutant males, the proportion of plug positive females is significantly reduced, probably due to production of malformed and smaller plugs that are more readily dissolved or dropped

• however, at 4 hrs after coitus, plugs are detected in equivalent proportions of females mated with control or mutant males, indicating successful mating

endocrine/exocrine glands

abnormal seminal vesicle morphology ( J:137429 )

• although the size of lumen is reduced it is still filled with strongly eosinophilic secretions, suggestive of partly preserved epithelial secretory function

abnormal seminal vesicle epithelium morphology ( J:137429 )

• in the proximal region, the epithelial cells of mutant seminal vesicles appear to be quite low, cuboidal, and with very little cytoplasm, while the epithelial layer is less folded than normal

• in the distal region, the epithelium exhibits a normal, tall secretory morphology, with occasional small foci of hyperplastic epithelial cells and a decrease in the size of the acini

abnormal seminal vesicle muscle layer morphology ( J:137429 )

• the stromal smooth muscle layer appears disorganized and thinner than normal

small seminal vesicle ( J:137429 )

• at 8 weeks of age, the size of mutant seminal vesicles is only 55% of that in control littemates

decreased seminal vesicle weight ( J:137429 )

• at 8 weeks of age, the weight of seminal vesicle secretion and emptied gland is significantly reduced

cellular

abnormal sperm flagellum morphology ( J:137429 )

• during in vitro fertilization, sperm released from mutant cauda epididymis show an increase in abnormal coiled and bent tails with hairpin structures

coiled sperm flagellum ( J:137429 )

hairpin sperm flagellum ( J:137429 )

kinked sperm flagellum ( J:137429 )

Allelic Composition	Gt(ROSA)26Sor^tm1(JAG1)Xin/Gt(ROSA)26Sor⁺ Tg(Pbsn-cre)20Fwan/?
Genetic Background	involves: C57BL/6 * FVB/NCrl

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:238768 )

N	• prostate weight is similar to control • prostate histology is similar to control

Allelic Composition	Wdr77^tm2Zwan/Wdr77^tm2Zwan Tg(Pbsn-cre)20Fwan/0
Genetic Background	involves: C57BL/6J * FVB/NCrl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Pbsn-cre)20Fwan mutation (1 available)
Wdr77^tm2Zwan mutation (0 available); any Wdr77 mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal prostate gland anterior lobe morphology ( J:162922 )

• at 2 months of age the anterior lobe contains small glands and fewer epithelial foldings

abnormal prostate gland development ( J:162922 )

• expression analysis indicates a defect in epithelial cell differentiation

abnormal prostate gland branching morphogenesis ( J:162922 )

• significant impairment in the development of branches and ductal tips in all 3 lobes

abnormal prostate gland dorsolateral lobe morphology ( J:162922 )

• at 2 months of age the dorsolateral lobe has a few glands and clusters of small ducts composed of a simple low columnar epithelium

• these ducts resemble immature prostate

abnormal prostate gland duct morphology ( J:162922 )

• in the dorsolateral and ventral lobes clusters of small ducts composed of a simple low columnar epithelium are present

• these ducts resemble immature prostate

decreased prostate gland duct number ( J:162922 )

• decrease in the number of branches and terminal duct tips in all 3 lobes

abnormal prostate gland epithelium morphology ( J:162922 )

• the luminal epithelial layer is composed of cuboidal basal like cells rather than columnar secretory cells

prostate gland epithelial hyperplasia ( J:162922 )

• multifocal hyperproliferative epithelial cells are observed in every prostate lobe

• despite the presence of hyperproliferative cells no prostate tumors are detected in mice up to 6 months of age

small prostate gland ( J:162922 )

• about half the size of control glands

abnormal prostate gland ventral lobe morphology ( J:162922 )

• similar in appearance to the dorsolateral lobe

abnormal prostate gland physiology ( J:162922 )

• decrease in the protein concentrations in prostate gland secretions from intact males

endocrine/exocrine glands

abnormal prostate gland anterior lobe morphology ( J:162922 )

• at 2 months of age the anterior lobe contains small glands and fewer epithelial foldings

abnormal prostate gland development ( J:162922 )

• expression analysis indicates a defect in epithelial cell differentiation

abnormal prostate gland branching morphogenesis ( J:162922 )

• significant impairment in the development of branches and ductal tips in all 3 lobes

abnormal prostate gland dorsolateral lobe morphology ( J:162922 )

• at 2 months of age the dorsolateral lobe has a few glands and clusters of small ducts composed of a simple low columnar epithelium

• these ducts resemble immature prostate

abnormal prostate gland duct morphology ( J:162922 )

• in the dorsolateral and ventral lobes clusters of small ducts composed of a simple low columnar epithelium are present

• these ducts resemble immature prostate

decreased prostate gland duct number ( J:162922 )

• decrease in the number of branches and terminal duct tips in all 3 lobes

abnormal prostate gland epithelium morphology ( J:162922 )

• the luminal epithelial layer is composed of cuboidal basal like cells rather than columnar secretory cells

prostate gland epithelial hyperplasia ( J:162922 )

• multifocal hyperproliferative epithelial cells are observed in every prostate lobe

• despite the presence of hyperproliferative cells no prostate tumors are detected in mice up to 6 months of age

small prostate gland ( J:162922 )

• about half the size of control glands

abnormal prostate gland ventral lobe morphology ( J:162922 )

• similar in appearance to the dorsolateral lobe

abnormal prostate gland physiology ( J:162922 )

• decrease in the protein concentrations in prostate gland secretions from intact males

Allelic Composition	Scrib^tm1.1Phum/Scrib^tm1.1Phum Tg(Pbsn-cre)20Fwan/0
Genetic Background	involves: FVB/NCrl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scrib^tm1.1Phum mutation (0 available); any Scrib mutation (54 available)
Tg(Pbsn-cre)20Fwan mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

prostate gland hyperplasia ( J:178461 )

• 88% at 100 days, 75% at 200 days, and 90% at 400 days

increased prostate intraepithelial neoplasia incidence ( J:178461 )

• low-grade

abnormal prostate gland physiology ( J:178461 )

• increase in cell proliferation compared with control

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:178461 )

• low-grade

endocrine/exocrine glands

prostate gland hyperplasia ( J:178461 )

• 88% at 100 days, 75% at 200 days, and 90% at 400 days

increased prostate intraepithelial neoplasia incidence ( J:178461 )

• low-grade

abnormal prostate gland physiology ( J:178461 )

• increase in cell proliferation compared with control

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