Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(Scx-GFP)1Stzr transgene insertion 1, Ronen Schweitzer MGI:3717419 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• some tendon fibers connecting forearm muscles to skeletal elements in the handplate are thinner than in controls and some have fused together
• in forelimb, tendons develop functional entheses on the forming skeleton
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• with tamoxifen treatment at E9.5, limbs display minor skeletal deformities similar to those in humans with Holt-Oram syndrome (triphalangeal thumb)
• muscle patterning is disrupted similarly to that with tamoxifen treatment at E10.5
• patterning of tendon fibers connecting forearm muscles to skeletal elements in the handplate is significantly disrupted compared to wild-type; fewer tendon fibers are present
• mispatterned muscles make functional myotendinous attachments to tendons
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• some tendon fibers connecting forearm muscles to skeletal elements in the handplate are thinner than in controls and some have fused together
• in forelimb, tendons develop functional entheses on the forming skeleton
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• the extensor carpi radialis longus/brevis, extensor digitorium communis, and extensor digiti quarti/quinti tendons are absent in the forelimb at E18.5
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• mice display limb contractures at E18.5
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• the extensor carpi radialis longus/brevis, extensor digitorium communis, and extensor digiti quarti/quinti tendons are absent in the forelimb at E18.5
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• limb tendons are lost with some missing completely and others small and rudimentary
• the extensor digitorium communis tendon ends are the wrist
• the extensor digiti quinti and carpi ulnaris tendons are reduced
• flexor tendons are more severely affected than extensors
• tail tendons are missing
• short tendons in the trunk are reduced or disrupted while long tendons are missing
• intermuscular tendons including the lateral tendious stripes in the rectus abdominis muscle, subscapularis musclea at the ventral side of the scapula, and the middle tendon of the diaphragm can not be detected
• however, anchoring tendons are normal and mice are mobile
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• mice cannot use their tails
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• tail tendons are missing
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• limb tendons are lost with some missing completely and others small and rudimentary
• the extensor digitorium communis tendon ends are the wrist
• the extensor digiti quinti and carpi ulnaris tendons are reduced
• flexor tendons are more severely affected than extensors
• tail tendons are missing
• short tendons in the trunk are reduced or disrupted while long tendons are missing
• intermuscular tendons including the lateral tendious stripes in the rectus abdominis muscle, subscapularis musclea at the ventral side of the scapula, and the middle tendon of the diaphragm can not be detected
• however, anchoring tendons are normal and mice are mobile
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice are viable with no overt phenotype
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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