Phenotypes associated with this allele

• Allele Symbol: Tg(Thy1-APPSw)1Vln
• Allele Name: transgene insertion 1, Fred Van Leuven
• Allele ID: MGI:3717574
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Thy1-APPSw)1Vln/0	involves: FVB/N	MGI:3717580

Genotype
MGI:3717580

tg1

• Allelic Composition: Tg(Thy1-APPSw)1Vln/0
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:53800 )

• 72.2% of animals died by 180 days of age compared to 4.3% of controls by 360 days

nervous system

seizures ( J:53800 )

• less than 15% of mice older than 6 months display spontaneous seizures

behavior/neurological

abnormal response to new environment ( J:53800 )

• ambulation measured in a corner-crossing variant upon transfer to a new cage is reduced relative to controls at 4-9 weeks of age, 12-17, and 20-52 weeks with differences becoming more pronounced with age

hyperactivity ( J:53800 )

• mice show increased episodes of agitation and spontaneous activity at >8 weeks of age

seizures ( J:53800 )

• less than 15% of mice older than 6 months display spontaneous seizures

homeostasis/metabolism

amyloidosis ( J:53800 )

• mice younger than 12 months do not exhibit amyloid deposits

• diffuse amyloid plaques and compact neuritic plaques are detected in >50% of mice 18-25 months old